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Cadherin 5 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Cadherin 5 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 2+ Publikationen erwähnt.
Produktnummer ABIN3042913

Kurzübersicht für Cadherin 5 Antikörper (C-Term) (ABIN3042913)

Target

Alle Cadherin 5 (CDH5) Antikörper anzeigen
Cadherin 5 (CDH5)

Reaktivität

  • 118
  • 68
  • 47
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 91
  • 51
  • 15
  • 1
Kaninchen

Klonalität

  • 87
  • 71
Polyklonal

Konjugat

  • 103
  • 9
  • 7
  • 5
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Cadherin 5 Antikörper ist unkonjugiert

Applikation

  • 119
  • 70
  • 53
  • 52
  • 43
  • 41
  • 16
  • 14
  • 14
  • 13
  • 13
  • 7
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 16
    • 13
    • 9
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 766-784, C-Term

    Verwendungszweck

    Anti-VE-Cadherin CDH5-Antibody Picoband®

    Sequenz

    RFKMLAELYG SDPREELLY

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-VE-Cadherin CDH5-Antibody (ABIN3042913). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human VE Cadherin, different from the related mouse and rat sequences by three amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
    1. Huber, P., Dalmon, J., Engiles, J., Breviario, F., Gory, S., Siracusa, L. D., Buchberg, A. M., Dejana, E. Genomic structure and chromosomal mapping of the mouse VE-cadherin gene (Cdh5). Genomics 32: 21-28, 1996. 2. Kremmidiotis, G., Baker, E., Crawford, J., Eyre, H. J., Nahmias, J., Callen, D. F. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. Genomics 49: 467-471, 1998.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Dai, Chen, Lin, Wang, Guo, Zhang: "Exposure to Concentrated Ambient Fine Particulate Matter Induces Vascular Endothelial Dysfunction via miR-21." in: International journal of biological sciences, Vol. 13, Issue 7, pp. 868-877, (2018) (PubMed).

    Liu, Zhu, Xiong, Zheng, Hu, Qiu: "Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells." in: International journal of clinical and experimental pathology, Vol. 7, Issue 9, pp. 5750-61, (2014) (PubMed).

  • Target

    Cadherin 5 (CDH5)

    Andere Bezeichnung

    CDH5

    Hintergrund

    Synonyms: Cadherin-5,7B4 antigen,Vascular endothelial cadherin,VE-cadherin,CD144,CDH5,

    Tissue Specificity: Endothelial tissues and brain.

    Background: CDH5 (Cadherin 5), also known as VE-cadherin, is a type of cadherin. It is encoded by the human gene CDH5. Kremmidiotis et al. (1998) mapped the human CDH5 gene to 16q22.1 using somatic cell hybrid panels. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Therefore it was concluded that VE-cadherin serves the purpose of maintaining newly formed vessels.

    Sequence Similarities: Belongs to the annexin family.

    Molekulargewicht

    130 kDa

    UniProt

    P33151

    Pathways

    Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2
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