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M-CSF/CSF1 Antikörper (AA 33-262)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch M-CSF/CSF1 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Maus und Ratte und wurde in 1 Publikation erwähnt.
Produktnummer ABIN3042763

Kurzübersicht für M-CSF/CSF1 Antikörper (AA 33-262) (ABIN3042763)

Target

Alle M-CSF/CSF1 (CSF1) Antikörper anzeigen
M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Reaktivität

  • 98
  • 47
  • 15
  • 9
  • 6
  • 5
  • 3
  • 2
  • 1
Maus, Ratte

Wirt

  • 97
  • 16
  • 6
  • 2
  • 2
  • 1
Kaninchen

Klonalität

  • 96
  • 25
  • 2
Polyklonal

Konjugat

  • 65
  • 10
  • 9
  • 4
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser M-CSF/CSF1 Antikörper ist unkonjugiert

Applikation

  • 83
  • 47
  • 40
  • 15
  • 13
  • 13
  • 13
  • 12
  • 10
  • 10
  • 10
  • 6
  • 4
  • 2
  • 2
  • 2
  • 1
ELISA, Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 9
    • 8
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 33-262

    Verwendungszweck

    Anti-MCSF/CSF1 Antibody

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-MCSF/CSF1 Antibody Picoband® (ABIN3042763). Tested in ELISA, IHC applications. This antibody reacts with Mouse, Rat.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E. coli-derived mouse MCSF recombinant protein (Position: K33-E262). Mouse MCSF shares 80.9 % and 88.6% amino acid (aa) sequence identity with human and rat MCSF, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    ELISA, 0.1-0.5 μg/mL, -
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat
    1. Fixe P, Praloran V (June 1997)."Macrophage colony-stimulating-factor (M-CSF or CSF-1) and its receptor: structure-function relationships". Eur. Cytokine Netw. 8 (2): 125-36. 2. Nemunaitis J (April 1993). "Macrophage function activating cytokines: potential clinical application". Crit. Rev. Oncol. Hematol. 14 (2): 153-71. 3. Stanley ER, Berg KL, Einstein DB, Lee PS, Pixley FJ, Wang Y, Yeung YG (January 1997). "Biology and action of colony--stimulating factor-1". Mol. Reprod. Dev. 46(1): 4-10.

    Kommentare

    Antibody can be supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Pei, Sun, Zhang, Wang, Ren: "Interstitial tumor-associated macrophages combined with tumor-derived colony-stimulating factor-1 and interleukin-6, a novel prognostic biomarker in non-small cell lung cancer." in: The Journal of thoracic and cardiovascular surgery, Vol. 148, Issue 4, pp. 1208-1216.e2, (2015) (PubMed).

  • Target

    M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

    Andere Bezeichnung

    Csf1

    Hintergrund

    Synonyms: Macrophage colony-stimulating factor 1,CSF-1,MCSF,Processed macrophage colony-stimulating factor 1,Csf1,Csfm,

    Tissue Specificity: Non-neural epithelial tissues.

    Background: M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival ofmonocytes, macrophages, and bone marrow progenitor cells. M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy.

    Sequence Similarities: Contains 5 cadherin domains.

    Molekulargewicht

    130 kDa

    Gen-ID

    12977

    UniProt

    P07141

    Pathways

    RTK Signalweg
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