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CNTF Antikörper (AA 2-198)

Der Kaninchen Polyklonal Anti-CNTF-Antikörper wurde für WB und IHC validiert. Er ist geeignet, CNTF in Proben von Ratte und Maus zu detektieren.
Produktnummer ABIN3042752

Kurzübersicht für CNTF Antikörper (AA 2-198) (ABIN3042752)

Target

Alle CNTF Antikörper anzeigen
CNTF (Ciliary Neurotrophic Factor (CNTF))

Reaktivität

  • 74
  • 47
  • 23
  • 18
  • 4
  • 2
  • 1
Ratte, Maus

Wirt

  • 87
  • 15
  • 4
  • 3
  • 1
  • 1
Kaninchen

Klonalität

  • 97
  • 14
Polyklonal

Konjugat

  • 61
  • 11
  • 10
  • 6
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CNTF Antikörper ist unkonjugiert

Applikation

  • 90
  • 50
  • 32
  • 31
  • 30
  • 13
  • 13
  • 9
  • 7
  • 6
  • 6
  • 5
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 13
    • 10
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-198

    Verwendungszweck

    Anti-CNTF Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-CNTF Antibody Picoband® (ABIN3042752). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived mouse CNTF recombinant protein (Position: A2-M198). Mouse CNTF shares 83% and 95% amino acid (aa) sequences identity with human and rat CNTF, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Mouse
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat
    1. Lam, A., Fuller, F., Miller, J., Kloss, J., Manthorpe, M., Varon, S., Cordell, B. Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. Gene 102: 271-276, 1991. 2. Watt, M. J., Dzamko, N., Thomas, W. G., Rose-John, S., Ernst, M., Carling, D., Kemp, B. E., Febbraio, M. A., Steinberg, G. R. CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nature Med. 12: 541-548, 2006.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    CNTF (Ciliary Neurotrophic Factor (CNTF))

    Andere Bezeichnung

    CNTF

    Hintergrund

    Synonyms: Ciliary neurotrophic factor,CNTF,Cntf,

    Tissue Specificity: Nervous system.

    Background: Ciliary neurotrophic factor (CNTF) is a potent polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes survival, neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The mouse CNTF gene is on mouse chromosome 19 and that its expression is unaffected in the mouse neurologic mutant wobbler, a form of spinal muscular atrophy. The CNTF protein is highly conserved in evolution. The protein is a potent survival factor for neurons and oligodendrocytes, and it may be involved in reducing tissue destruction during inflammatory attacks. CNTF is thought to act centrally by inducing hypothalamic neurogenesis to modulate food intake and peripherally by altering hepatic gene expression, in a manner similar to that of leptin.

    Sequence Similarities: Belongs to the intercrine beta (chemokine CC) family.

    Molekulargewicht

    29 kDa

    Gen-ID

    12803

    UniProt

    P51642

    Pathways

    JAK-STAT Signalweg
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