CX3CL1 Antikörper (N-Term)

Produktnummer ABIN3042714

Dieses Anti-CX3CL1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CX3CL1 in WB und IHC. Geeignet für Ratte und Maus.

Kurzübersicht für CX3CL1 Antikörper (N-Term) (ABIN3042714)

Target: CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CX3CL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-CX3CL1 Antikörper

Bindungsspezifität: AA 74-92, N-Term

Verwendungszweck: Anti-Fractalkine CX3CL1 Antibody Picoband®

Sequenz: CADPKEKWVQ DAMKHLDHQ

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Fractalkine CX3CL1 Antibody (ABIN3042714). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse CX3CL1, identical to the related rat sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Mouse, Rat, -
Western blot, 0.1-0.5 μg/mL, Mouse, Rat
1. Pan et al., Lloyd C, Zhou H, Dolich S, Deeds J, Gonzalo JA, Vath J, Gosselin M et al. (1997). "Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation". Nature 387 (6633): 611-617. doi:10.1038/42491. PMID 9177350. 2. Bazan et al., Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A et al. (1997). "A new class of membrane-bound chemokine with a CX3C motif". Nature 385 (6617): 640-644. doi:10.1038/385640a0. PMID 9024663. 3. Hannan, N. J., Jones, R. L., Critchley, H. O. D., Kovacs, G. J., Rogers, P. A. W., Affandi, B., Salamonsen, L. A.Coexpression of fractalkine and its receptor in normal human endometrium and in endometrium from users of progestin-only contraception supports a role of fractalkine in leukocyte recruitment and endometrial remodeling.J. Clin. Endocr. Metab.89: 6119-6129, 2004.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CX3CL1

Target: CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))

Andere Bezeichnung: CX3CL1

Hintergrund:

Synonyms: Fractalkine,C-X3-C motif chemokine 1,CX3C membrane-anchored chemokine,Neurotactin,Small-inducible cytokine D1,Processed fractalkine,Cx3cl1,Cx3c, Fkn, Scyd1,

Tissue Specificity: Highest levels in brain. Lower levels in kidney, heart and lung. Also found in skeletal muscle and testis.

Background: Chemokine (C-X3-C motif) ligand 1, also known as CX3CL1, is a large cytokine protein. It is said to be the only known member of the CX3C chemokine family. It is also commonly known under the names fractalkine (in humans) and neurotactin (in mice). Its gene is mapped to the long arm of chromosome 8. Being the large protein, it has got 373 amino acids. Imai et al. (1997) identified a 7-transmembrane high-affinity receptor (CX3CR1, 601470) for fractalkine and showed that it mediates both the adhesive and migratory functions of fractalkine.

Molekulargewicht: 90-100 kDa

UniProt: O35188

Pathways: Synaptic Membrane