MUC5AC Antikörper (N-Term)

Produktnummer ABIN3042535

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MUC5AC in IHC und WB. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für MUC5AC Antikörper (N-Term) (ABIN3042535)

Target: MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUC5AC Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-MUC5AC Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: Anti-Mucin 5AC/MUC5AC Antibody

Sequenz: TMQLFMQLAP KLRGQT

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Mucin 5AC/MUC5AC Antibody. Tested in IHC, WB applications. This antibody reacts with Human.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Mucin 5AC.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-MUC5AC Antikörper (ABIN3042535)

Meziu, Shehu, Koch, Schneider, Kraegeloh: "Impact of mucus modulation by N-acetylcysteine on nanoparticle toxicity." in: International journal of pharmaceutics: X, Vol. 6, pp. 100212, (2023) (PubMed).

Jin, Kenny, Skoog, Padra, Adamczyk, Vitizeva, Thorell, Venkatakrishnan, Lindén, Karlsson: "Structural Diversity of Human Gastric Mucin Glycans." in: Molecular & cellular proteomics : MCP, Vol. 16, Issue 5, pp. 743-758, (2018) (PubMed).

Zhou, Perelman, Kolosov, Zhou: "Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2." in: Molecular and cellular biochemistry, Vol. 377, Issue 1-2, pp. 75-85, (2013) (PubMed).

Details zu MUC5AC

Target: MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))

Andere Bezeichnung: MUC5AC

Hintergrund:

Background: Mucin-5AC is a protein that in humans is encoded by the MUC5AC gene. It is mapped to 11p15.5. MUC5AC is highly expressed in adult trachea and stomach. This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease (COPD). It has been showed that activation of the NF-kappa-B signaling pathway by inflammatory cytokine TNF-alpha upregulated MUC5AC mRNA expression nearly 6-fold. MUC5AC is also a and critical mediator of resistance during intestinal nematode infection.

Gene Full Name: mucin 5AC, oligomeric mucus/gel-forming

Sequence Similarities: Contains 1 CTCK (C-terminal cystine knot-like) domain.

Molekulargewicht: 300 kDa

Gen-ID: 4586

UniProt: P98088