MUC5AC Antikörper (AA 4848-5030)

Produktnummer ABIN3043460

Produktdetails anti-MUC5AC Antikörper

Target: MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))

Bindungsspezifität: AA 4848-5030

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUC5AC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Mucin-5AC(MUC5AC) detection. Tested with WB, IHC-P in Human.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Mucin-5AC(MUC5AC) detection. Tested with WB, IHC-P in Human.
Gene Name: mucin 5AC, oligomeric mucus/gel-forming
Protein Name: Mucin-5AC

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Mucin 5AC recombinant protein (Position: D4848-H5030).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Mucin 5AC is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-MUC5AC Antikörper (ABIN3043460)

Zhou, Perelman, Kolosov, Zhou: "Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2." in: Molecular and cellular biochemistry, Vol. 377, Issue 1-2, pp. 75-85, (2013) (PubMed).

Details zu MUC5AC

Target: MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))

Andere Bezeichnung: MUC5AC (MUC5AC Produkte)

Synonyme: MUC5 antikoerper, TBM antikoerper, leB antikoerper, 2210005L13Rik antikoerper, MGM antikoerper, mucin 5AC, oligomeric mucus/gel-forming antikoerper, putative gastric mucin antikoerper, mucin 5, subtypes A and C, tracheobronchial/gastric antikoerper, mucin 2, oligomeric mucus/gel-forming antikoerper, MUC5AC antikoerper, Smp_144070 antikoerper, Muc5ac antikoerper, MUC2 antikoerper

Hintergrund: Mucin-5AC is a protein that in humans is encoded by the MUC5AC gene. It is mapped to 11p15.5. MUC5AC is highly expressed in adult trachea and stomach. This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease(COPD). It has been showed that activation of the NF-kappa-B signaling pathway by inflammatory cytokine TNF-alpha upregulated MUC5AC mRNA expression nearly 6-fold. MUC5AC is also a direct and critical mediator of resistance during intestinal nematode infection.

Synonyms: Apomucin antibody|Gastric mucin antibody|LeB antibody|Lewis B blood group antigen antibody|Major Airway Glycoprotein antibody|MUC 5 antibody|MUC5 antibody|MUC5AC antibody|Mucin 5 subtype AC tracheobronchial antibody|Mucin 5 Subtypes A And C antibody|Mucin 5 subtypes A and C tracheobronchial/gastric antibody|Mucin 5AC antibody|Mucin 5AC oligomeric mucus/gel forming antibody|Mucin 5AC, oligomeric mucus/gel forming pseudogene antibody|TBM antibody|Tracheobronchial Mucin antibody

Gen-ID: 4586

UniProt: P98088