Thrombospondin 1 Antikörper (N-Term)

Produktnummer ABIN3042477

Der Kaninchen Polyklonal anti-Thrombospondin 1 Antikörper (ABIN3042477) detektiert spezifisch Thrombospondin 1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Thrombospondin 1 Antikörper (N-Term) (ABIN3042477)

Target: Thrombospondin 1 (THBS1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Thrombospondin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Thrombospondin 1 Antikörper

Bindungsspezifität: AA 58-86, N-Term

Verwendungszweck: Anti-Thrombospondin/THBS1 Antibody

Sequenz: AFRIEDANLI PPVPDDKFQD LVDAVRAEK

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Thrombospondin/THBS1 Antibody (ABIN3042477). Tested in WB applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human THBS1, different from the related mouse sequence by five amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu Thrombospondin 1

Target: Thrombospondin 1 (THBS1)

Andere Bezeichnung: THBS1

Hintergrund:

Synonyms: Thrombospondin-1,THBS1,TSP, TSP1,

Tissue Specificity: Mainly expressed in the brain and adrenal glands.

Background: THBS1 is also known as Thrombospondin 1, TSP1. The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. It is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Also this protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. In addition, the thrombospondin-1 protein is a member of the thrombospondinfamily. It is a multi-domain matrix glycoprotein that has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. Both positive and negative modulation of endothelial cell adhesion, motility, and growth have been attributed to TSP1. This should not be surprising considering that TSP1 interacts with at least 12 cell adhesion receptors, including CD36, αv integrins, β1 integrins, syndecan, and integrin-associated protein (IAP or CD47). It also interacts with numerous proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase.

Sequence Similarities: Belongs to the thrombospondin family.

Molekulargewicht: 190 kDa

Gen-ID: 7057

UniProt: P07996

Pathways: Autophagie