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HSPG2 Antikörper (AA 524-701)

HSPG2 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3042466
  • Target Alle HSPG2 Antikörper anzeigen
    HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))
    Bindungsspezifität
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 524-701
    Reaktivität
    • 28
    • 19
    • 6
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Human
    Wirt
    • 21
    • 7
    • 5
    Kaninchen
    Klonalität
    • 22
    • 11
    Polyklonal
    Konjugat
    • 23
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HSPG2 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 17
    • 10
    • 10
    • 9
    • 6
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Verwendungszweck
    Anti-Heparan Sulfate Proteoglycan 2/HSPG2 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-Heparan Sulfate Proteoglycan 2/HSPG2 Antibody Picoband® (ABIN3042466). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human HSPG2 recombinant protein (Position: F524-K701). Human HSPG2 shares 86% amino acid (aa) sequence identity with mouse HSPG2.
    Isotyp
    IgG
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    Discover our top product HSPG2 Primärantikörper
  • Applikationshinweise
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Arikawa-Hirasawa E, Le AH, Nishino I, Nonaka I, Ho NC, Francomano CA et al. (May 2002). 2. Iozzo RV (1994). "Perlecan: a gem of a proteoglycan". Matrix Biol. 14 (3): 203-8. 3. Kallunki P, Eddy RL, Byers MG, Kestilä M, Shows TB, Tryggvason K (October 1991). "Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1----p35 and identification of a BamHI restriction fragment length polymorphism". Genomics 11 (2): 389-96.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))
    Andere Bezeichnung
    HSPG2 (HSPG2 Produkte)
    Hintergrund

    Synonyms: Basement membrane-specific heparan sulfate proteoglycan core protein,HSPG,Perlecan,PLC,Endorepellin,LG3 peptide,HSPG2,

    Tissue Specificity: Found in the basement membranes.

    Background: Perlecan (PLC) also known as HSPG2, is a protein that in humans is encoded by the HSPG2 gene. It is mapped to 1p36.12. Perlecan is highly conserved across species and the available data indicate that it has evolved from ancient ancestors by gene duplication and exonshuffling. Perlecan is a key component of the vascular extracellular matrix, here it interacts with a variety of other matrix components and helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. Perlecan can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation.

    Sequence Similarities: Contains 4 EGF-like domains.

    Molekulargewicht
    469 kDa
    Gen-ID
    3339
    UniProt
    P98160
    Pathways
    Glycosaminoglycan Metabolic Process, Lipid Metabolism
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