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HSPG2 Antikörper (AA 524-701)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HSPG2 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN3042466

Kurzübersicht für HSPG2 Antikörper (AA 524-701) (ABIN3042466)

Target

Alle HSPG2 Antikörper anzeigen
HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))

Reaktivität

  • 30
  • 20
  • 8
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
Human

Wirt

  • 23
  • 10
  • 5
Kaninchen

Klonalität

  • 24
  • 14
Polyklonal

Konjugat

  • 27
  • 5
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser HSPG2 Antikörper ist unkonjugiert

Applikation

  • 25
  • 22
  • 13
  • 11
  • 10
  • 7
  • 6
  • 5
  • 5
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 524-701

    Verwendungszweck

    Anti-Heparan Sulfate Proteoglycan 2/HSPG2 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Heparan Sulfate Proteoglycan 2/HSPG2 Antibody Picoband® (ABIN3042466). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human HSPG2 recombinant protein (Position: F524-K701). Human HSPG2 shares 86% amino acid (aa) sequence identity with mouse HSPG2.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Arikawa-Hirasawa E, Le AH, Nishino I, Nonaka I, Ho NC, Francomano CA et al. (May 2002). 2. Iozzo RV (1994). "Perlecan: a gem of a proteoglycan". Matrix Biol. 14 (3): 203-8. 3. Kallunki P, Eddy RL, Byers MG, Kestilä M, Shows TB, Tryggvason K (October 1991). "Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1----p35 and identification of a BamHI restriction fragment length polymorphism". Genomics 11 (2): 389-96.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))

    Andere Bezeichnung

    HSPG2

    Hintergrund

    Synonyms: Basement membrane-specific heparan sulfate proteoglycan core protein,HSPG,Perlecan,PLC,Endorepellin,LG3 peptide,HSPG2,

    Tissue Specificity: Found in the basement membranes.

    Background: Perlecan (PLC) also known as HSPG2, is a protein that in humans is encoded by the HSPG2 gene. It is mapped to 1p36.12. Perlecan is highly conserved across species and the available data indicate that it has evolved from ancient ancestors by gene duplication and exonshuffling. Perlecan is a key component of the vascular extracellular matrix, here it interacts with a variety of other matrix components and helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. Perlecan can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation.

    Sequence Similarities: Contains 4 EGF-like domains.

    Molekulargewicht

    469 kDa

    Gen-ID

    3339

    UniProt

    P98160

    Pathways

    Glycosaminoglycan Metabolic Process, Lipid Metabolism
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