HMOX1 Antikörper (AA 1-288)

Produktnummer ABIN3042449

Der Kaninchen Polyklonal Anti-HMOX1-Antikörper wurde für WB und IHC validiert. Er ist geeignet, HMOX1 in Proben von Human zu detektieren. Es sind 18+ Publikationen verfügbar.

Kurzübersicht für HMOX1 Antikörper (AA 1-288) (ABIN3042449)

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMOX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-HMOX1 Antikörper

Bindungsspezifität: AA 1-288

Verwendungszweck: Anti-Heme Oxygenase 1/HMOX1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Heme Oxygenase 1/HMOX1 Antibody Picoband® (ABIN3042449). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human HMOX1 recombinant protein (Position: M1-M288). Human HMOX1 shares 82% and 80% amino acid (aa) sequences identity with mouse and rat HMOX1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
1. He, C. H., Gong, P., Hu, B., Stewart, D., Choi, M. E., Choi, A. M. K., Alam, J.Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein: implication for heme oxygenase-1 gene regulation. J. Biol. Chem. 276: 20858-20865, 2001. 2. Piantadosi CA, Withers CM, Bartz RR, MacGarvey NC, Fu P, Sweeney TE, Welty-Wolf KE, Suliman HB (May 2011). "Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression". J. Biol. Chem.286 (18): 16374-85.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Referenzen für anti-HMOX1 Antikörper (ABIN3042449)

Wei, Kong, Li, Guan, Wang, Miao: "Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway." in: Scientific reports, Vol. 7, Issue 1, pp. 717, (2018) (PubMed).

Zhu, Chen, Chen, Yang, Xie: "Astaxanthin Promotes Nrf2/ARE Signaling to Alleviate Renal Fibronectin and Collagen IV Accumulation in Diabetic Rats." in: Journal of diabetes research, Vol. 2018, pp. 6730315, (2018) (PubMed).

Wu, Li, Cui, Wu, Hong, Li, Wu, Jie, Wang, Li: "The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway." in: Frontiers in pharmacology, Vol. 9, pp. 497, (2018) (PubMed).

Li Volti, Avola, Tibullo: "Commentary: The apolipoprotein A-I mimetic peptide, D-4F, restrains neointimal formation through heme oxygenase-1 up-regulation." in: Frontiers in pharmacology, Vol. 8, pp. 708, (2017) (PubMed).

Wang, Li, Chen, Jiang, Lu, Zhao: "Hydrogen sulfide accelerates wound healing in diabetic rats." in: International journal of clinical and experimental pathology, Vol. 8, Issue 5, pp. 5097-104, (2016) (PubMed).

Chen, Wang, Li, Jiang, Lu, Zhou: "Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats." in: Journal of diabetes research, Vol. 2016, pp. 9726503, (2016) (PubMed).

Guo, Li, Duan, Wang, Zhou, Sun: "Octreotide attenuates liver fibrosis by inhibiting hepatic heme oxygenase-1 expression." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 83-90, (2015) (PubMed).

Guo, Duan, Wang, Zhou, Li, Sun: "Endogenous carbon monoxide downregulates hepatic cystathionine-γ-lyase in rats with liver cirrhosis." in: Experimental and therapeutic medicine, Vol. 10, Issue 6, pp. 2039-2046, (2015) (PubMed).

Qin, Luo, Gu, Yang, Shen, Gu, Zhang, Gao: "Evidence for a therapeutic effect of Braintone on ischemic brain damage." in: Neural regeneration research, Vol. 8, Issue 19, pp. 1743-55, (2014) (PubMed).

Chen, Wei, He, Yu, Mang, Xu: "Changes of hypoxia-inducible factor-1 signaling and the effect of cilostazol in chronic cerebral ischemia." in: Neural regeneration research, Vol. 8, Issue 19, pp. 1803-13, (2014) (PubMed).

Liu, Wang, Qian, Li: "Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis." in: International journal of molecular medicine, Vol. 34, Issue 6, pp. 1492-504, (2014) (PubMed).

Li, Han, Li, Jiang, Wang: "Upregulation of heat shock protein 32 in Sertoli cells alleviates the impairments caused by heat shock-induced apoptosis in mouse testis." in: Cell stress & chaperones, Vol. 18, Issue 3, pp. 333-51, (2013) (PubMed).

Wang, Li, Lu, Zhao, Xu: "Taurine attenuates oxidative stress and alleviates cardiac failure in type I diabetic rats." in: Croatian medical journal, Vol. 54, Issue 2, pp. 171-9, (2013) (PubMed).

Wang, Li, Lu, Zhao: "Riboflavin alleviates cardiac failure in Type I diabetic cardiomyopathy." in: Heart international, Vol. 6, Issue 2, pp. e21, (2012) (PubMed).

Guo, Duan, Li, Sun: "Effect of heme oxygenase-1 on renal function in rats with liver cirrhosis." in: World journal of gastroenterology, Vol. 17, Issue 3, pp. 322-8, (2011) (PubMed).

Xia, Liu, Zhou, Tang, Zou: "Comparison of the effects of propofol and midazolam on inflammation and oxidase stress in children with congenital heart disease undergoing cardiac surgery." in: Yonsei medical journal, Vol. 52, Issue 2, pp. 326-32, (2011) (PubMed).

Wang, Duan, Sun: "Influence of heme oxygenase-1 expression on immune liver fibrosis induced by cobalt protoporphyrin in rats." in: World journal of gastroenterology, Vol. 15, Issue 24, pp. 3009-14, (2009) (PubMed).

Xue, Guo, Li, Hao: "Heme oxygenase-1 induction by hemin protects liver cells from ischemia/reperfusion injury in cirrhotic rats." in: World journal of gastroenterology, Vol. 13, Issue 40, pp. 5384-90, (2007) (PubMed).

Details zu HMOX1

Target: HMOX1 (Heme Oxygenase (Decycling) 1 (HMOX1))

Andere Bezeichnung: HMOX1

Hintergrund:

Synonyms: Heme oxygenase 1,HO-1,1.14.99.3,HMOX1,HO, HO1,

Tissue Specificity: Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level). .

Background: HMOX1 (heme oxygenase (decycling) 1), also known as HO-1, is a human gene that encodes for the enzyme heme oxygenase 1. It is an essential enzyme in heme catabolism, it cleaves heme to form biliverdin. HMOX1 belongs to the heme oxygenase family. The HMOX1 gene is located on the long (q) arm of chromosome 22 at position 12.3, from base pair 34,101,636 to base pair 34,114,748. HMOX1, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. HMOX1 activity is induced by its substrate heme and by various nonheme substances.

Sequence Similarities: Belongs to the heme oxygenase family.

Molekulargewicht: 33 kDa

Gen-ID: 3162

UniProt: P09601

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, SARS-CoV-2 Protein Interaktom