GRK5 Antikörper (C-Term)

Produktnummer ABIN3042434

Der Kaninchen Polyklonal Anti-GRK5-Antikörper wurde für WB und IHC validiert. Er ist geeignet, GRK5 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für GRK5 Antikörper (C-Term) (ABIN3042434)

Target: GRK5 (G Protein-Coupled Receptor Kinase 5 (GRK5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRK5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-GRK5 Antikörper

Bindungsspezifität: AA 393-429, C-Term

Verwendungszweck: Anti-GRK5 Antibody Picoband®

Sequenz: KREEVDRRVL ETEEVYSHKF SEEAKSICKM LLTKDAK

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-GRK5 Antibody Picoband® (ABIN3042434). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human GRK5, different from the related mouse and rat sequences by three amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
1. "Entrez Gene: GRK5 G protein-coupled receptor kinase 5". 2. Bullrich F, Druck T, Kunapuli P, et al. (1995). "Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6.". Cytogenet. Cell Genet. 70 (3-4): 250-4. 3. Kunapuli P, Benovic JL (Jul 1993). "Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family". Proc Natl Acad Sci U S A 90 (12): 5588-92.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu GRK5

Target: GRK5 (G Protein-Coupled Receptor Kinase 5 (GRK5))

Andere Bezeichnung: GRK5

Hintergrund:

Synonyms: G protein-coupled receptor kinase 5,2.7.11.16,G protein-coupled receptor kinase GRK5,GRK5,GPRK5,

Tissue Specificity: Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney. .

Background: G protein-coupled receptor kinase 5?is an?enzyme?that in humans is encoded by the?GRK5?gene. It is mapped to 10q26.11. This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).

Molekulargewicht: 68 kDa

Gen-ID: 2869

UniProt: P34947

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling