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FURIN Antikörper (AA 591-794)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FURIN in WB. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN3042409

Kurzübersicht für FURIN Antikörper (AA 591-794) (ABIN3042409)

Target

Alle FURIN Antikörper anzeigen
FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Reaktivität

  • 46
  • 38
  • 18
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Human

Wirt

  • 65
  • 5
  • 1
Kaninchen

Klonalität

  • 53
  • 18
Polyklonal

Konjugat

  • 36
  • 12
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser FURIN Antikörper ist unkonjugiert

Applikation

  • 41
  • 32
  • 22
  • 19
  • 15
  • 13
  • 13
  • 4
  • 4
  • 3
  • 3
Western Blotting (WB)
  • Bindungsspezifität

    • 15
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 591-794

    Verwendungszweck

    Anti-Furin Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Furin Antibody Picoband® (ABIN3042409). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human Furin recombinant protein (Position: T591-L794). Human Furin shares 88% amino acid (aa) sequence identity with both mouse and rat Furin.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human
    1. Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ, Kaufman RJ (Jan 1991). "Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site". Proc Natl Acad Sci U S A 87(23): 9378-82. 2. Hallenberger S, Bosch V, Angliker H, Shaw E, Klenk HD, Garten W (November 1992). "Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160". Nature 360 (6402): 358-61. 3. Thomas G (October 2002). "Furin at the cutting edge: from protein traffic to embryogenesis and disease". Nat. Rev. Mol. Cell Biol. 3 (10): 753-66.doi:10.1038/nrm934. 4. Roebroek, A. J. M., Schalken, J. A., Leunissen, J. A. M., Onnekink, C., Bloemers, H. P. J., Van de Ven, W. J. M. Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein. EMBO J. 5: 2197-2202, 1986.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

    Andere Bezeichnung

    FURIN

    Hintergrund

    Synonyms: Furin,3.4.21.75,Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE,FURIN,FUR, PACE, PCSK3,

    Tissue Specificity: Seems to be expressed ubiquitously.

    Background: Furin (Fur), also known as PACE, is a protein that in humans is encoded by the FURIN gene. The protein encoded by this gene is an enzyme which belongs to the subtilisin-like proprotein convertase family. The Furin gene is located approximately 1 kb upstream of the FES gene on chromosome 15q25-q26. This gene is thought to play a role in tumor progression. Furin is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. Expression of furin in T-cells is required for maintenance of peripheral immune tolerance.

    Sequence Similarities: Belongs to the peptidase S8 family. Furin subfamily.

    Molekulargewicht

    87 kDa

    Gen-ID

    5045

    UniProt

    P09958

    Pathways

    Notch Signalweg, Neurotrophin Signalübertragung
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