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FGFR4 Antikörper (AA 22-206)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FGFR4 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN3042391

Kurzübersicht für FGFR4 Antikörper (AA 22-206) (ABIN3042391)

Target

Alle FGFR4 Antikörper anzeigen
FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Reaktivität

  • 88
  • 37
  • 26
  • 1
  • 1
Human

Wirt

  • 72
  • 18
  • 2
  • 1
Kaninchen

Klonalität

  • 65
  • 25
  • 2
Polyklonal

Konjugat

  • 50
  • 8
  • 7
  • 4
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser FGFR4 Antikörper ist unkonjugiert

Applikation

  • 52
  • 41
  • 23
  • 22
  • 13
  • 13
  • 12
  • 11
  • 7
  • 6
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 15
    • 11
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 22-206

    Verwendungszweck

    Anti-FGFR4 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-FGFR4 Antibody Picoband® (ABIN3042391). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human FGFR4 recombinant protein (Position: L22-H206). Human FGFR4 shares 86% and 84% amino acid (aa) sequences identity with mouse and rat FGFR4, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Lesca, E., Lammens, A., Huber, R., Augustin, M. "Structural analysis of the human Fibroblast Growth Factor Receptor 4 kinase". J. Mol. Biol. 2. "Entrez Gene: FGFR4 fibroblast growth factor receptor 4"

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

    Andere Bezeichnung

    FGFR4

    Hintergrund

    Synonyms: Fibroblast growth factor receptor 4,FGFR-4,2.7.10.1,CD334,FGFR4,JTK2, TKF,

    Tissue Specificity: Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. .

    Background: FGFR4 (Fibroblast growth factor receptor 4), also known as CD334, is a protein that in humans is encoded by the FGFR4 gene. It is mapped to 5q35.2. The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. It is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

    Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

    Molekulargewicht

    100 kDa

    Gen-ID

    2264

    UniProt

    P22455

    Pathways

    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding
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