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NUMB Antikörper (AA 194-220)

Der Kaninchen Polyklonal Anti-NUMB-Antikörper wurde für WB validiert. Er ist geeignet, NUMB in Proben von Human und Maus zu detektieren.
Produktnummer ABIN3032081

Kurzübersicht für NUMB Antikörper (AA 194-220) (ABIN3032081)

Target

Alle NUMB Antikörper anzeigen
NUMB (Numb Homolog (NUMB))

Reaktivität

  • 60
  • 48
  • 20
  • 6
  • 4
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 65
  • 11
  • 2
  • 1
Kaninchen

Klonalität

  • 59
  • 20
Polyklonal

Konjugat

  • 51
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser NUMB Antikörper ist unkonjugiert

Applikation

  • 63
  • 20
  • 17
  • 13
  • 13
  • 9
  • 7
  • 7
  • 7
  • 6
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 15
    • 6
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 194-220

    Aufreinigung

    Antigen affinity

    Immunogen

    Amino acids 194-220 (SFRVTTATEQAEREEIMKQMQDAKKAE-human) were used as the immunogen for this Numb antibody.

    Isotyp

    IgG
  • Applikationshinweise

    The stated application concentrations are suggested starting amounts. Titration of the Numb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    Lagerung

    -20 °C

    Informationen zur Lagerung

    After reconstitution, the Numb antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target

    NUMB (Numb Homolog (NUMB))

    Andere Bezeichnung

    Numb

    Hintergrund

    Numb is a protein that in humans is encoded by the gene of the same name. The encoded protein, whose degradation is induced in a proteasome-dependent manner by < a href=../search_result.php?search_txt=mdm>MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of < a href=../search_result.php?search_txt=notch>Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. Additionally, the protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.

    Gen-ID

    8650

    Pathways

    Cell-Cell Junction Organization
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