NUMB Antikörper (AA 194-220)

Produktnummer ABIN3032081

Produktdetails anti-NUMB Antikörper

Target: NUMB (Numb Homolog (NUMB))

Bindungsspezifität: AA 194-220

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUMB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: Amino acids 194-220 (SFRVTTATEQAEREEIMKQMQDAKKAE-human) were used as the immunogen for this Numb antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Numb antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Numb antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu NUMB

Target: NUMB (Numb Homolog (NUMB))

Andere Bezeichnung: Numb (NUMB Produkte)

Hintergrund: Numb is a protein that in humans is encoded by the gene of the same name. The encoded protein, whose degradation is induced in a proteasome-dependent manner by < a href=../search_result.php?search_txt=mdm>MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of < a href=../search_result.php?search_txt=notch>Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. Additionally, the protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.

Gen-ID: 8650

Pathways: Cell-Cell Junction Organization