Tec Protein Tyrosine Kinase (TEC) (AA 612-631) Antikörper

Produktnummer ABIN3032066

Der Kaninchen Polyklonal anti-Tec Protein Tyrosine Kinase Antikörper wird verwendet zum Nachweis von Tec Protein Tyrosine Kinase in Proben von Human und Ratte. Er wurde validiert für WB und IHC (p).

Kurzübersicht für Tec Protein Tyrosine Kinase (TEC) (AA 612-631) Antikörper (ABIN3032066)

Target: Tec Protein Tyrosine Kinase (TEC)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails

Bindungsspezifität: AA 612-631

Aufreinigung: Antigen affinity

Immunogen: Amino acids 612-631 (FEDLLRTIDELVECEETFGR-human) were used as the immunogen for this Tec antibody (100% rat homology).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Tec antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Tec antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Antigendetails

Target: Tec Protein Tyrosine Kinase (TEC)

Andere Bezeichnung: Tec

Hintergrund: TEC Protein Tyrosine Kinase, is an enzyme that in humans is encoded by the TEC gene. The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. By fluorescence in situ hybridization, Sato et al.(1994) mapped the gene to 4p12, the same location reported for TXK. Mouse Tec is a non-receptor type protein-tyrosine kinase that is highly expressed in many hematopoietic cell lines. Hantschel et al.(2007) identified TEC kinase and BTK kinase as major binders of the tyrosine kinase inhibitor dasatinib, which is used for treatment of BCR/ABL-positive CML.

UniProt: P42680

Pathways: Fc-epsilon Rezeptor Signalübertragung