CASP5 Antikörper (Center)

Produktnummer ABIN303202

Produktdetails anti-CASP5 Antikörper

Target: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Bindungsspezifität: Center

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CASP5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide corresponding to 14 amino acid peptide from the center of human Caspase-5.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections (5 μg/mL). Immunocytochemistry. Western Blot (0.5-1 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline PBS, containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer. Dilute only prior to immediate use.

Details zu CASP5

Target: CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))

Andere Bezeichnung: Caspase-5 (CASP5 Produkte)

Synonyme: ICE(rel)III antikoerper, ICEREL-III antikoerper, ICH-3 antikoerper, CASP5 antikoerper, caspase 5 antikoerper, caspase-5 antikoerper, CASP5 antikoerper, LOC100437308 antikoerper

Hintergrund: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18. Caspase-5 can interact with caspase-1, both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1b. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-g.Synonyms: CASP-5, CASP5, ICE(rel)-III, ICH-3 protease, ICH3, TY protease

Gen-ID: 838

NCBI Accession: NP_001129581

UniProt: P51878

Pathways: Inflammasome