CARD11 Antikörper (C-Term)

Produktnummer ABIN303197

Der Kaninchen Polyklonal anti-CARD11 Antikörper wird verwendet zum Nachweis von CARD11 in Proben von Human und Maus. Er wurde validiert für WB und IHC (p).

Kurzübersicht für CARD11 Antikörper (C-Term) (ABIN303197)

Target: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CARD11 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot (0.5-2 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline, containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C to -70 °C for longer. Dilute only prior to immediate use.

Details zu CARD11

Target: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Andere Bezeichnung: CARD11 / CARMA1

Hintergrund: CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the IkK complex, thereby regulating activation of the NF-kB transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.Synonyms: CARD-containing MAGUK protein 3, Caspase recruitment domain-containing protein 11

Gen-ID: 84433

NCBI Accession: NP_115791

UniProt: Q9BXL7

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, BCR Signaling