FOXO3 Antikörper (AA 471-673)

Produktnummer ABIN3030992

Der Kaninchen Polyklonal Anti-FOXO3-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, FOXO3 in Proben von Human und Ratte zu detektieren.

Kurzübersicht für FOXO3 Antikörper (AA 471-673) (ABIN3030992)

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXO3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FOXO3 Antikörper

Bindungsspezifität: AA 471-673

Aufreinigung: Antigen affinity

Immunogen: Human partial recombinant protein (AA 471-673) was used as the immunogen for this FOXO3A antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the FOXO3A antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the FOXO3A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu FOXO3

Target: FOXO3 (Forkhead Box O3 (FOXO3))

Andere Bezeichnung: FOXO3A

Hintergrund: Forkhead box O3, also known as FKHRL1 or FOXO3A, is a human protein encoded by the FOXO3 gene. FOXO3A belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. It is mapped to 6q21. This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim and< a href=../search_result.php?search_txt=puma>PUMA, or downregulation of anti-apoptotic proteins such as FLIP. In mammals FOXO3A regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life span. In addition, it is thought that FOXO3A is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD.

Gen-ID: 2309

Pathways: Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis