DLL3 Antikörper (AA 599-618)

Produktnummer ABIN3030711

Dieses Anti-DLL3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DLL3 in WB. Geeignet für Human.

Kurzübersicht für DLL3 Antikörper (AA 599-618) (ABIN3030711)

Target: DLL3 (delta Like Protein 3 (DLL3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DLL3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DLL3 Antikörper

Bindungsspezifität: AA 599-618

Aufreinigung: Antigen affinity

Immunogen: Amino acids 599-618 (RAGQRQHLLFPYPSSILSVK-human) were used as the immunogen for this DLL3 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the DLL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the DLL3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu DLL3

Target: DLL3 (delta Like Protein 3 (DLL3))

Andere Bezeichnung: DLL3

Hintergrund: Delta-like 3 is a protein which in humans is encoded by the DLL3 gene. This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutation in the mouse delta-like 3 gene, which is homologous to the Notch-ligand delta in Drosophila, results in the mouse 'pudgy' phenotype. The human gene was identified within a critical interval, mapped in two consanguineous Arab-Israeli and Pakistani SCDO1 pedigrees, of 7.8 cM at 19q13.1-q13.3 between D19S570 and D19S908(Bulman et al., 2000). Dunwoodie et al.(1997) presented results suggesting that mouse DLL3 may complement the function of other delta homologs during early pattern formation in the mouse embryo. In humans, the fact that mutations in genes required for oscillation, such as DLL3, result in abnormal segmentation of the vertebral column suggests that the segmentation clock also acts during human embryonic development. This residue is highly conserved in Delta proteins from Drosophila to humans, and the substitution of a charged polar for a nonpolar residue may disrupt the conformation of the DLL3 protein.

UniProt: Q9NYJ7

Pathways: Notch Signalweg