Caspase 10 Antikörper (AA 220-236)

Produktnummer ABIN3030289

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Caspase 10 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Caspase 10 Antikörper (AA 220-236) (ABIN3030289)

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Caspase 10 Antikörper

Bindungsspezifität: AA 220-236

Aufreinigung: Antigen affinity

Immunogen: Amino acids 220-236 (VKTFLEALPRAAVYRMN-human) were used as the immunogen for this Caspase-10 antibody. This sequence is from the large subunit

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Caspase-10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Caspase-10 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Caspase 10

Target: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Andere Bezeichnung: Caspase-10

Hintergrund: Caspase-10 is an enzyme that in humans is encoded by the CASP10 gene. The CASP10 gene contains 11 exons and spans about 48 kb. This gene is mapped to 2q33.1. It is transcribed in the centromere-to-telomere direction. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates CASP3 and 7, and the protein itself is processed by CASP8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this protein.

UniProt: Q92851

Pathways: Apoptose, Caspase Kaskade in der Apoptose