CTBP1 Antikörper (AA 425-440)

Produktnummer ABIN3030237

Dieses Anti-CTBP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CTBP1 in WB und IHC (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für CTBP1 Antikörper (AA 425-440) (ABIN3030237)

Target: CTBP1 (C-terminal Binding Protein 1 (CTBP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CTBP1 Antikörper

Bindungsspezifität: AA 425-440

Aufreinigung: Antigen affinity

Immunogen: Amino acids 425-440 (QTVKPEADRDHASDQL-human) were used as the immunogen for this CtBP1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the CtBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the CtBP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu CTBP1

Target: CTBP1 (C-terminal Binding Protein 1 (CTBP1))

Andere Bezeichnung: CtBP1

Hintergrund: C-terminal-binding protein 1 is encoded by the CTBP1 gene. It binds to the C-terminus of adenovirus E1A proteins. It is a transcriptional repressor(corepressor) and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. CtBP1 and CtBP2 preferentially associate with the E1A via a 5 amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T cell development, CtBP1 and -2 associate with the PLDLSL domain of delta EF1, a cellular zinc finger-homeodomain protein, and thereby enhances delta EF1-induced transcriptional silencing. In addition, CtBP complexes with CtIP, a 125 kDa protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.

UniProt: Q13363

Pathways: Retinoic Acid Receptor Signaling Pathway