Angiopoietin 2 Antikörper (AA 454-468)

Produktnummer ABIN3029949

Produktdetails anti-Angiopoietin 2 Antikörper

Target: Angiopoietin 2 (ANGPT2)

Bindungsspezifität: AA 454-468

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Angiopoietin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: Amino acids 454-468 (NLNGMYYPQRQNTNK-human) were used as the immunogen for this Angiopoietin 2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Angiopoietin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Angiopoietin 2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Angiopoietin 2

Target: Angiopoietin 2 (ANGPT2)

Andere Bezeichnung: Angiopoietin 2 (ANGPT2 Produkte)

Synonyme: AGPT2 antikoerper, ANG2 antikoerper, Agpt2 antikoerper, Ang-2 antikoerper, Ang2 antikoerper, ang2 antikoerper, angpt2 antikoerper, ANGIOPOIETIN-2 antikoerper, ANG-2 antikoerper, ANGPT2 antikoerper, Angrp antikoerper, Rnase5b antikoerper, ANG3 antikoerper, C11orf2 antikoerper, C11orf3 antikoerper, FFR antikoerper, angiopoietin 2 antikoerper, angiopoietin 2b antikoerper, angiogenin, ribonuclease A family, member 2 antikoerper, VPS51, GARP complex subunit antikoerper, ANGPT2 antikoerper, Angpt2 antikoerper, angpt2b antikoerper, Ang2 antikoerper, VPS51 antikoerper

Hintergrund: Angiopoietin 2 and -1 are involved in the development of the endothelium by regulating tyrosine phosphorylation of the membrane receptor Tie 2. Angiopoietin 2 is only 60 % homologous with -1. It is a naturally occurring antagonist of ANGPT1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation. ANGPT1 binding to Tie 2 causes phosphorylation of the receptor. Angiopoietin 2 competes for this binding, and thus blocks receptor phosphorylation. Angiopoietin 2 expression occurs at sites of vascular remodelling: dorsal aorta and major aortic branches, ovary, placenta and uterus.

UniProt: O15123

Pathways: RTK Signalweg