IL23A Antikörper

Produktnummer ABIN302824

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch IL23A in WB, IHC (p) und IF. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für IL23A Antikörper (ABIN302824)

Target: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL23A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-IL23A Antikörper

Spezifität: This antibody reacts to a 16 amino acid peptide from near the carboxy terminus of IL-23.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide

Anwendungsinformationen

Applikationshinweise: Western Blot: 2 - 4 μg/mL. Immunohistochemistry: 5 μg/mL. Imunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline, containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu IL23A

Target: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Andere Bezeichnung: Interleukin-23 alpha / IL23A

Hintergrund: IL23 is composed of the IL12 p40 subunit and a p19 subunit (IL23P19 or IL23A). The p19 subunit shares sequence similarity with IL6 subfamily members and is distantly related to the p35 subunit of IL12. It shows no biological activity by itself, instead, it combines with the p40 subunit of IL12 to form a biologically active, composite cytokine, IL23. IL12 and IL23 are molecules mainly produced by activated accessory and antigen-presenting cells. Both IL23 and IL12 can activate the transcription activator STAT4. In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. IL12 used to be thought to be the prime-regulator of TH1 development but upon discovery of IL23 and the fact that the large subunit of IL23 is shared by IL12, it is now thought that the features attributed to IL12 and TH1 development in inflammation are, in fact, dependent on IL23 rather than IL12. IL23 is implicated in protective and autoimmune responses.Synonyms: IL-23 subunit alpha, IL-23p19, Interleukin-23 subunit p19, SGRF

Gen-ID: 51561

NCBI Accession: NP_057668

UniProt: Q9NPF7

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation