ErbB2/Her2 Antikörper

Produktnummer ABIN3026574

Der Maus Monoklonal anti-ErbB2/Her2 Antikörper wird verwendet zum Nachweis von ErbB2/Her2 in Proben von Human und Ratte. Er wurde validiert für IF und FACS.

Kurzübersicht für ErbB2/Her2 Antikörper (ABIN3026574)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ErbB2/Her2 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: HRB2-258

Produktdetails anti-ErbB2/Her2 Antikörper

Produktmerkmale: This antibody recognizes a protein of 185 kDa, which is identified as HER2 / ErbB2. Its epitope is localized in the extracellular domain. ErbB2 is a member of the EGFR family. This antibody is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. ErbB2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

Aufreinigung: Protein G purified

Immunogen: Recombinant human protein was used as the immunogen for this ErbB2 antibody.(1)

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Variations in protocols, secondaries and substrates may require the antibody to be titered for optimal performance.

1. This ErbB2 antibody binds to the extracellular/cell surface region of the protein.\. FACS: 0.5-1 μg/million cells,IF: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the ErbB2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Details zu ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Andere Bezeichnung: ErbB2 HER2

Hintergrund: This antibody recognizes a protein of 185  kDa, which is identified as HER2 / ErbB2. Its epitope is localized in the extracellular domain. ErbB2 is a member of the EGFR family. This antibody is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. ErbB2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development