BACE1 Antikörper (Internal Region)

Produktnummer ABIN302584

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BACE1 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für BACE1 Antikörper (Internal Region) (ABIN302584)

Target: BACE1 (Beta-secretase 1 (BACE1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BACE1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BACE1 Antikörper

Bindungsspezifität: Internal Region

Spezifität: This antibody deztects Beta-site APP-Cleaving Enzyme 1 (BACE1) at internal domain.

Aufreinigung: Immunoaffinity chromatography

Immunogen: BACE1 antibody was raised against synthetic peptide from internal domain of human BACE1.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections (2.5 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 °C to 8 °C up to one month or (in aliquots) at -20 °C to -70 °C for longer.

Details zu BACE1

Target: BACE1 (Beta-secretase 1 (BACE1))

Andere Bezeichnung: BACE1

Hintergrund: Bace 1 is responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.Synonyms: ASP2, Aspartyl protease 2, BACE, BACE-1, Beta-secretase 1, Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, KIAA1149, Memapsin-2, Membrane-associated aspartic protease 2

Gen-ID: 23621

NCBI Accession: NP_036236

UniProt: P56817