PODXL Antikörper (Extracellular, Intracellular, Transmembrane Domain)

Produktnummer ABIN3025409

Dieser Maus Monoklonal Antikörper detektiert spezifisch PODXL in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für PODXL Antikörper (Extracellular, Intracellular, Transmembrane Domain) (ABIN3025409)

Target: PODXL (Podocalyxin-Like (PODXL))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PODXL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: 2A4

Produktdetails anti-PODXL Antikörper

Bindungsspezifität: Extracellular, Intracellular, Transmembrane Domain

Verwendungszweck: Podocalyxin Antibody (azide and preservative free)

Aufreinigung: PEG precipitation

Immunogen: A recombinant protein fragment containing the intracellular, transmembrane, and part of the extracellular domain of human PODXL was used as the immunogen for the Podocalyxin antibody.

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Podocalyxin antibody should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Podocalyxin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu PODXL

Target: PODXL (Podocalyxin-Like (PODXL))

Andere Bezeichnung: Podocalyxin

Hintergrund: Podocalyxin/PODXL is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology.

UniProt: O00592

Pathways: Tube Formation