PDE8B Antikörper (Internal Region)

Produktnummer ABIN302525

Der Kaninchen Polyklonal anti-PDE8B Antikörper wird verwendet zum Nachweis von PDE8B in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für PDE8B Antikörper (Internal Region) (ABIN302525)

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE8B Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-PDE8B Antikörper

Bindungsspezifität: Internal Region

Spezifität: This antibody detects Phosphodiesterase 8B (PDE8B) at internal domain.

Aufreinigung: Immunoaffinity chromatography

Immunogen: PDE8B antibody was raised against synthetic peptide from internal domain of human PDE8B.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin sections (5 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,3 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Details zu PDE8B

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Andere Bezeichnung: PDE8B

Hintergrund: Phosphodiesterase 8B, is a high affinity, cAMP-specific phosphodiesterase. Enhanced PDE8B activity has been associated with the phenotypic expression of Gsalpha mutations in human pituitary tumors. PDE8B is absent in normal pituitary but present in GH-secreting adenomas. PDE8B activity is inhibited by dipyridamole, but it is insensitive to rolipram, zaprinast, or IBMX.Synonyms: 5'-cyclic phosphodiesterase 8B, ADSD, Cell proliferation-inducing gene 22 protein, High affinity cAMP-specific and IBMX-insensitive 3', PIG22, PPNAD3, Phosphodiesterase 8B, hsPDE8B

Gen-ID: 8622

NCBI Accession: NP_001025022

UniProt: O95263

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process