LSD1 Antikörper (N-Term)

Produktnummer ABIN3025191

Der Kaninchen Polyklonal anti-LSD1 Antikörper wird verwendet zum Nachweis von LSD1 in Proben von Human und Maus. Er wurde validiert für WB und IHC (p).

Kurzübersicht für LSD1 Antikörper (N-Term) (ABIN3025191)

Target: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LSD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-LSD1 Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Protein A affinity chromatography

Immunogen: A recombinant protein fragment from the N-terminal region of human LSD1 / KDM1 was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Provided assay concentrations are suggestions only, LSD1 / KDM1 antibody titration may be required for optimal results.\. Western blot: 0.5-2 μg/mL, IHC (FFPE): 5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the LSD1 / KDM1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu LSD1

Target: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Andere Bezeichnung: LSD1 / KDM1

Hintergrund: LSD1 (Lysine-specific demethylase 1), also called KDM1 (lysine (K)-specific demethylase 1A), is the first histone demethylase to be identified and regulates transcription via demethylation of lysines 4 and 9 of Histone H3. It negatively regulates pro-inflammatory cytokine expression by interacting with the genes promoter region. It also plays a role in tumor development where overexpression of LSD1 correlates with a poor prognosis. It is upregulated in cancers of the bladder, breast, lung, colon, and GI tract as well as neuroblastoma and cells of mesenchymal origin such as chondrosarcoma, osteosarcoma, rhabdomyosarcoma and Ewing's sarcoma (Bennani-Baiti et al, 2012).

Gen-ID: 23028

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effekt