HDAC2 Antikörper (C-Term)

Produktnummer ABIN3022867

Zitiert in 3+ Publikationen. Dieser Anti-HDAC2-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von HDAC2 in WB, IHC und IP. Geeignet für Human.

Kurzübersicht für HDAC2 Antikörper (C-Term) (ABIN3022867)

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-HDAC2 Antikörper

Bindungsspezifität: C-Term

Sequenz: VHEDSGDEDG EDPDKRISIR ASDKRIACDE EFSDSEDEGE GGRRNVADHK KGAKKARIEE DKKETEDKKT DVKEEDKSKD NSGEKTDTKG TKSEQLSNP

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 390 to the C-terminus of human HDAC2 (NP_001518.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-HDAC2 Antikörper (ABIN3022867)

Fan, Li, Wang, Emerson, Xu: "A Novel ZIP4-HDAC4-VEGFA Axis in High-Grade Serous Ovarian Cancer." in: Cancers, Vol. 13, Issue 15, (2021) (PubMed).

Wei, Liu, Chen, Gao, Lu, Zhang, Ding, Wang, Chen, Shi, Li, Yu, Wong: "Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription." in: Cell research, Vol. 27, Issue 7, pp. 898-915, (2018) (PubMed).

Li, Liu, He, Yang, Pei, Li, Liu, Chen, Xie, Xu, Ting, Zhang, Jin, Liu, Zhang, Yuan, Yang, Wu, Zhang, Yang, Yi, Liang, Shang, Sun: "ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin." in: Nature communications, Vol. 8, Issue 1, pp. 691, (2018) (PubMed).

Details zu HDAC2

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Andere Bezeichnung: HDAC2

Hintergrund: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.,HD2,RPD3,YAF1,HDAC2,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Deacetylation,Nuclear Receptor Signaling,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,G1/S Checkpoint,Notch Signaling Pathway,Wnt/β-Catenin Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Stem Cells,Cardiovascular,Heart,Hypertrophy,HDAC2

Molekulargewicht: 51 kDa/55 kDa

Gen-ID: 3066

UniProt: Q92769

Pathways: Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion