IL25 Antikörper (Interleukin 25) (AA 115-132)

Details for Product anti-IL25 Antibody No. ABIN302245, Anbieter: Anmelden zum Anzeigen
Antigen
  • IL17E
  • IL-17e
  • Il17e
  • IL25
  • RGD1561632
  • interleukin 25
  • IL25
  • Il25
Epitop
AA 115-132
17
12
12
9
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8
8
5
5
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3
3
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2
2
1
1
1
1
Reaktivität
Human, Maus
210
96
21
1
Wirt
Maus
114
78
45
30
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser IL25 Antikörper ist unkonjugiert
19
15
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12
10
9
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8
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4
4
4
4
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2
2
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
184
96
81
59
33
20
17
13
8
6
5
3
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen A synthetic peptide of amino acids 115-132, obtained from the human IL-17E proteinsequence.
Klon 68C1039-2
Isotyp IgG1
Spezifität This antibody detects Interleukin 17E (IL17E) (IL25).
Kreuzreaktivität (Details) Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
Produktmerkmale Synonyms: IL-25, IL17E, IL-17E, Interleukin-17E
Reinigung Protein G Chromatography.
Plasmids, Primers & others Plasmide, Primers & weitere IL25 products on genomics-online (e.g. as negative or positive controls)
Andere Bezeichnung Interleukin-25 / IL25 (IL25 Antibody Abstract)
Hintergrund Recently, a number of cytokines belonging to the interleukin (IL)-17 family have been identified. These are termed as IL-17B, IL-17C and IL-17E. IL-17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL-17B, C, and E like IL-17 are able to induce proinflammatory responses. However, they do not bind to the IL-17 receptor suggesting that additional IL-17R related receptor might exist. Receptor for IL-17B and IL-17E has been independently isolated by Shi, et al and Lee, et al. and has been designated as EV127 (in mouse) and IL-17Rh1 (in human), respectively. IL-17E induces activation of NF-kB pathway and like IL-17 also induces production of IL-8. The IL17 proteins are a family of potent cytokines that act to induce proinflammatory responses. Studies have shown that IL17E binds strongly to IL17RB. Receptor binding of ligand has been shown to lead to the activation of nuclear factor kappa-B and production of IL8. Exposure of mice to IL17 resulted in a Th-2 like response characterized by increased serum IgE, IgG1 and IgA levels, blood eosinophilia, increased lymphocytes and neutrophils, and pathological changes in the tissues that included eosinophilic infiltrates, increased mucus production, B-lymphocyte hyperplasia and epithelial cell hyperplasia/hypertrophy.Synonyms: IL-17E, IL-25, IL17E, Interleukin-17E
Gen-ID 64806
UniProt Q9H293
Applikations-hinweise Western blot (2 μg/mL). Immunohistochemistry on Paraffin Sections (10 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove fromheat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween(TBST) for 1 min. at room temperature.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.5 mg/mL
Buffer PBS containing 0.05 % Sodium Azide as preservative.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or(in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Haltbarkeit 12 months
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Interleukin 25 (IL25) (AA 115-132) antibody (ABIN302245) anti-Interleukin 25 (IL25) (AA 115-132) antibody
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