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Endoglin Antikörper (PE)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Endoglin in FACS. Er zeigt eine Reaktivität gegenüber Human und Schwein.
Produktnummer ABIN302200

Kurzübersicht für Endoglin Antikörper (PE) (ABIN302200)

Target

Alle Endoglin (ENG) Antikörper anzeigen
Endoglin (ENG)

Reaktivität

  • 217
  • 72
  • 71
  • 20
  • 19
  • 16
  • 15
  • 3
  • 3
  • 3
  • 2
  • 1
Human, Schwein

Wirt

  • 133
  • 119
  • 21
  • 3
  • 2
  • 1
Maus

Klonalität

  • 152
  • 126
  • 1
Monoklonal

Konjugat

  • 120
  • 31
  • 28
  • 24
  • 15
  • 7
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Endoglin Antikörper ist konjugiert mit PE

Applikation

  • 166
  • 159
  • 90
  • 55
  • 49
  • 33
  • 29
  • 25
  • 25
  • 18
  • 13
  • 10
  • 7
  • 6
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS)

Klon

MEM-229
  • Spezifität

    This antibody recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Human and Porcine.

    Produktmerkmale

    Synonyms: ENG, END, HHT1, ORW, ORW1

    Aufreinigung

    Size-Exclusion Chromatography

    Immunogen

    Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA

    Isotyp

    IgG2a
  • Applikationshinweise

    Flow Cytometry analysis of Human blood cells using 20 μL reagent/100 μL of whole blood or10^6 cells in a suspension.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    Phosphate buffered saline (PBS) containing 15 mM Sodium Azide and 0.2 % (w/v) high-grade protease free BSA as a stabilizing agent.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store the antibody at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
    Shelf life: one year from despatch.

    Haltbarkeit

    12 months
  • Target

    Endoglin (ENG)

    Andere Bezeichnung

    CD105 / Endoglin

    Hintergrund

    CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbR-2 as a receptor for TGFb-1 and TGFb-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFb-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.Synonyms: END, ENG, HHT1, ORW, ORW1

    UniProt

    P17813
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