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BDNF Antikörper (AA 20-247)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BDNF in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.
Produktnummer ABIN3021893

Kurzübersicht für BDNF Antikörper (AA 20-247) (ABIN3021893)

Target

Alle BDNF Antikörper anzeigen
BDNF (Brain-Derived Neurotrophic Factor (BDNF))

Reaktivität

  • 139
  • 80
  • 65
  • 22
  • 17
  • 15
  • 10
  • 9
  • 8
  • 8
  • 7
  • 6
  • 3
  • 3
  • 1
Human

Wirt

  • 135
  • 57
  • 6
  • 3
  • 2
  • 2
Kaninchen

Klonalität

  • 137
  • 67
Polyklonal

Konjugat

  • 131
  • 19
  • 12
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser BDNF Antikörper ist unkonjugiert

Applikation

  • 168
  • 102
  • 78
  • 68
  • 50
  • 24
  • 19
  • 13
  • 13
  • 12
  • 6
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 16
    • 14
    • 14
    • 13
    • 13
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 20-247

    Sequenz

    PMKEANIRGQ GGLAYPGVRT HGTLESVNGP KAGSRGLTSL ADTFEHVIEE LLDEDQKVRP NEENNKDADL YTSRVMLSSQ VPLEPPLLFL LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCRGI DKRHWNSQCR TTQSYVRALT MDSKKRIGWR FIRIDTSCVC TLTIKRGR

    Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Polyclonal Antibodies

    Aufreinigung

    Affinity purification

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 20-247 of human BDNF (NP_733928.1).

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:500 - 1:2000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid freeze / thaw cycles

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Sidler, Aitken, Jiang, Sotiropoulos, Aggarwal, Anees, Chong, Siebenaller, Thanabalasingam, White, Choufani, Weksberg, Sangiorgi, Wrana, Delgado-Olguin, Bägli et al.: "DNA Methylation Reduces the Yes-Associated Protein 1/WW Domain Containing Transcription Regulator 1 Pathway and Prevents Pathologic Remodeling during Bladder Obstruction by Limiting Expression of ..." in: The American journal of pathology, Vol. 188, Issue 10, pp. 2177-2194, (2018) (PubMed).

    Hang, Zhao, Sun, Li, Han, Du, Li: "Brain-derived neurotrophic factor attenuates doxorubicin-induced cardiac dysfunction through activating Akt signalling in rats." in: Journal of cellular and molecular medicine, Vol. 21, Issue 4, pp. 685-696, (2017) (PubMed).

    Hang, Sun, Guo, Zhao, Du: "BDNF-mediates Down-regulation of MicroRNA-195 Inhibits Ischemic Cardiac Apoptosis in Rats." in: International journal of biological sciences, Vol. 12, Issue 8, pp. 979-89, (2017) (PubMed).

  • Target

    BDNF (Brain-Derived Neurotrophic Factor (BDNF))

    Andere Bezeichnung

    BDNF

    Hintergrund

    This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders.,BDNF,ANON2,BULN2,Cell Biology & Developmental Biology,Apoptosis,Growth factor,Endocrine & Metabolism,Endocrine and metabolic diseases,Diabetes,Obesity,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Cardiovascular,BDNF

    Molekulargewicht

    27 kDa/28 kDa/29 kDa/31 kDa/37 kDa

    Gen-ID

    627

    UniProt

    P23560

    Pathways

    RTK Signalweg, Synaptic Membrane, Feeding Behaviour, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity
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