SMAD1 Antikörper (AA 20-240)

Produktnummer ABIN3021439

Dieses Anti-SMAD1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SMAD1 in WB, IHC und IF. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für SMAD1 Antikörper (AA 20-240) (ABIN3021439)

Target: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-SMAD1 Antikörper

Bindungsspezifität: AA 20-240

Sequenz: WKQGDEEEKW AEKAVDALVK KLKKKKGAME ELEKALSCPG QPSNCVTIPR SLDGRLQVSH RKGLPHVIYC RVWRWPDLQS HHELKPLECC EFPFGSKQKE VCINPYHYKR VESPVLPPVL VPRHSEYNPQ HSLLAQFRNL GQNEPHMPLN ATFPDSFQQP NSHPFPHSPN SSYPNSPGSS SSTYPHSPTS SDPGSPFQMP ADTPPPAYLP PEDPMTQDGS Q

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human Smad1 (NP_001003688.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-SMAD1 Antikörper (ABIN3021439)

Kong, Liang, Chen, Yang, Liu, Li, Feng, Wu, Liu, Tang, Yu, Ou, Lu, Yan: "Hyaluronan negatively regulates vascular calcification involving BMP2 signaling." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 98, Issue 10, pp. 1320-1332, (2018) (PubMed).

Details zu SMAD1

Target: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Andere Bezeichnung: SMAD1

Hintergrund: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.,BSP-1,BSP1,JV4-1,JV41,MADH1,MADR1,Smad1,SMAD1,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,TGF-b-Smad Signaling Pathway,ESC Pluripotency and Differentiation,Immunology & Inflammation,Stem Cells,SMADs,SMAD1

Molekulargewicht: 15 kDa/52 kDa

Gen-ID: 4086

UniProt: Q15797

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development