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AHNAK Antikörper (N-Term)

This anti-AHNAK antibody (ABIN302097) is a Mouse Monoclonal antibody detecting AHNAK in WB, IP, ICC, IHC (fro). Suitable for Human, Mouse.
Produktnummer ABIN302097

Kurzübersicht für AHNAK Antikörper (N-Term) (ABIN302097)

Target

Alle AHNAK Antikörper anzeigen
AHNAK (AHNAK Nucleoprotein (AHNAK))

Reaktivität

  • 48
  • 3
  • 1
Human, Maus

Wirt

  • 33
  • 13
  • 2
Maus

Klonalität

  • 38
  • 10
Monoklonal

Konjugat

  • 24
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser AHNAK Antikörper ist unkonjugiert

Applikation

  • 18
  • 15
  • 13
  • 13
  • 7
  • 7
  • 7
  • 4
  • 4
  • 3
  • 3
  • 1
  • 1
Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon

EM-09
  • Bindungsspezifität

    • 15
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term

    Verwendungszweck

    Anti-AHNAK1 Purified

    Spezifität

    The mouse monoclonal antibody EM-09 reacts with AHNAK1, a 700 kDa multi-functional adaptor protein expressed mainly in epithelial cell, various types of muscle cells and immune cells.

    Kreuzreaktivität (Details)

    Human, Mouse

    Aufreinigung

    Purified by protein-A affinity chromatography.

    Reinheit

    > 95 % (by SDS-PAGE)

    Immunogen

    Bacterially expressed fragment of N-terminal domain of human AHNAK1.

    Isotyp

    IgG1
  • Applikationshinweise

    Immunocytochemistry: Positive control: HeLa human cervix carcinoma cell line, permeabilization is required.
    Western blotting: Positive control: HeLa human cervix carcinoma cell line.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Johnson, Zhang, Adams, Phillips, Freitas, Froehner, Green-Church, Montanaro: "Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins." in: PLoS ONE, Vol. 7, Issue 8, pp. e43515, (2012) (PubMed).

  • Target

    AHNAK (AHNAK Nucleoprotein (AHNAK))

    Andere Bezeichnung

    AHNAK1

    Hintergrund

    AHNAK1 nucleoprotein,AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear, it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.,Desmoyokin

    Gen-ID

    79026

    UniProt

    Q09666
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