AHNAK Antikörper (N-Term)

Produktnummer ABIN263928

Produktdetails anti-AHNAK Antikörper

Target: AHNAK (AHNAK Nucleoprotein (AHNAK))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser AHNAK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: The antibody reacts with AHNAK1, a 700 kDa multi-functional adaptor protein expressed mainly in epithelial cell, various types of muscle cells and immune cells.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse.

Produktmerkmale: Synonyms: Desmoyokin, Neuroblast differentiation-associated protein AHNAK

Aufreinigung: Protein A Affinity Chromatography

Immunogen: Bacterially expressed fragment of N-terminal domain of human AHNAK1

Klon: EM-09

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on frozen sections. Western blot (Positive control: HeLa human cervix carcinoma cell line). Immunocytochemistry (Permeabilization is required, positive control: HeLa human cervixcarcinoma cell line). Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH ~7.4, 15 mM Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 to -80 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu AHNAK

Target: AHNAK (AHNAK Nucleoprotein (AHNAK))

Abstract: AHNAK Produkte

Synonyme: AHNAKRS antikoerper, 1110004P15Rik antikoerper, 2310047C17Rik antikoerper, AA589382 antikoerper, AV091586 antikoerper, DY6 antikoerper, AHNAK 1 antikoerper, RGD1308572 antikoerper, UV118 antikoerper, AHNAK antikoerper, wu:fb05a01 antikoerper, wu:fu74f12 antikoerper, LOC733715 antikoerper, AHNAK nucleoprotein antikoerper, AHNAK nucleoprotein (desmoyokin) antikoerper, AHNAK nucleoprotein pseudogene antikoerper, AHNAK antikoerper, Ahnak antikoerper, ahnak antikoerper, LOC748622 antikoerper

Hintergrund: AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear, it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.Synonyms: Desmoyokin, Neuroblast differentiation-associated protein AHNAK

Gen-ID: 79026

UniProt: Q09666