GRB2 Antikörper (AA 198-217)

Produktnummer ABIN302091

Dieses Anti-GRB2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GRB2 in WB. Geeignet für Human.

Kurzübersicht für GRB2 Antikörper (AA 198-217) (ABIN302091)

Target: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GRB2 Antikörper

Bindungsspezifität: AA 198-217

Verwendungszweck: Anti-GRB2 Purified

Spezifität: The polyclonal antibody recognizes Grb2, a highly conserved approximately 26 kDa intracellular adaptor protein. The immunogen has 100 % identity between man, cow, rat and mouse.

Kreuzreaktivität (Details): Human, Other species Not tested

Aufreinigung: Purified by ligand affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Synthetic peptide corresponding to C-terminus of human Grb2 (amino acids 198-217).

Anwendungsinformationen

Applikationshinweise: Western blotting: Recommended dilution: 1-2 μg/mL, reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Details zu GRB2

Target: GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))

Andere Bezeichnung: GRB2

Hintergrund: Growth factor receptor bound protein 2,Grb2 (growth factor receptor-bound protein 2) is a highly conserved adaptor protein composed of central SH2 domain flanked by two terminal SH3 domains. Grb2 mediates coupling of receptor protein tyrosine kinases to a guanine nucleotide exchange factor Sos, thereby enabling the tyrosine kinases to stimulate activity of Ras and hence of MAP kinase pathway. Grb2 also can bind to receptor protein tyrosine phosphatases and affect their signaling.,ASH, NCKAP2

Gen-ID: 2885

UniProt: P62993

Pathways: RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation