LAT Antikörper (Cytoplasmic Domain)
(2 Referenzen)-
- Target Alle LAT Antikörper anzeigen
- LAT (Linker For Activation of T Cells (LAT))
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Bindungsspezifität
- Cytoplasmic Domain
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser LAT Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunoprecipitation (IP), Intracellular Flow Cytometry (ICFC)
- Verwendungszweck
- Anti-LAT Purified
- Spezifität
- The antibody LAT-01 reacts with an intracellular epitope of LAT, a 36-38 kDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
- Keine Kreuzreaktivität
- Maus
- Kreuzreaktivität (Details)
- Human
- Aufreinigung
- Purified by protein-A affinity chromatography.
- Reinheit
- > 95 % (by SDS-PAGE)
- Immunogen
- Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of human LAT.
- Klon
- LAT-01
- Isotyp
- IgG1
- Top Product
- Discover our top product LAT Primärantikörper
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anti-Linker For Activation of T Cells (LAT) antibody
LAT Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr191) antibodyLAT Reaktivität: Human WB, ELISA, IHC, IP, IF Wirt: Kaninchen Monoclonal 2E4 unconjugated Recombinant Antibody
anti-Linker For Activation of T Cells (LAT) (pTyr226) antibodyLAT Reaktivität: Human WB, IHC (f) Wirt: Maus Monoclonal J96-1238-58-93 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 1-233) antibodyLAT Reaktivität: Human WB, ELISA, IHC (p) Wirt: Maus Monoclonal 3B11-1D5 unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr161) antibodyLAT Reaktivität: Human ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibodyLAT Reaktivität: Human WB, IHC, IP, IHC (p) Wirt: Maus Monoclonal LAT1111 unconjugated
anti-Linker For Activation of T Cells (LAT) antibodyLAT Reaktivität: Human BCA Wirt: Maus Monoclonal LAT1111 unconjugated
anti-Linker For Activation of T Cells (LAT) (Tyr255) antibodyLAT Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (Tyr660) antibodyLAT Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (Tyr659) antibodyLAT Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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Immunoprecipitation: Tyrosine-phosphorylated form of LAT is not optimally recognized.
Flow cytometry: Recommended dilution: 1-4 μg/mL, intracellular staining. Tyrosine-phosphorylated form of LAT is not optimally recognized.
Western blotting: Recommended dilution: 1-2 μg/mL. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Do not freeze.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Do not freeze.
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: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).
: "Transmembrane adaptor molecules: a new category of lymphoid-cell markers." in: Blood, Vol. 107, Issue 1, pp. 213-21, (2005) (PubMed).
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: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).
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- Target
- LAT (Linker For Activation of T Cells (LAT))
- Andere Bezeichnung
- LAT (LAT Produkte)
- Hintergrund
- Linker for activation of T cells,LAT (linker for activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.,IMD52
- Gen-ID
- 27040
- UniProt
- O43561
- Pathways
- T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
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