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LAT Antikörper (Cytoplasmic Domain)

Der Maus Monoklonal Anti-LAT-Antikörper wurde für WB, IP und ICFC validiert. Er ist geeignet, LAT in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.
Produktnummer ABIN302069

Kurzübersicht für LAT Antikörper (Cytoplasmic Domain) (ABIN302069)

Target

Alle LAT Antikörper anzeigen
LAT (Linker For Activation of T Cells (LAT))

Reaktivität

  • 129
  • 50
  • 33
  • 1
Human

Wirt

  • 115
  • 19
  • 2
  • 1
Maus

Klonalität

  • 115
  • 22
Monoklonal

Konjugat

  • 79
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
Dieser LAT Antikörper ist unkonjugiert

Applikation

  • 87
  • 48
  • 39
  • 39
  • 23
  • 21
  • 15
  • 12
  • 9
  • 6
  • 4
  • 4
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunoprecipitation (IP), Intracellular Flow Cytometry (ICFC)

Klon

LAT-01
  • Bindungsspezifität

    • 20
    • 15
    • 15
    • 10
    • 8
    • 8
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Domain

    Verwendungszweck

    Anti-LAT Purified

    Spezifität

    The antibody LAT-01 reacts with an intracellular epitope of LAT, a 36-38 kDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.

    Keine Kreuzreaktivität

    Maus

    Kreuzreaktivität (Details)

    Human

    Aufreinigung

    Purified by protein-A affinity chromatography.

    Reinheit

    > 95 % (by SDS-PAGE)

    Immunogen

    Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of human LAT.

    Isotyp

    IgG1
  • Applikationshinweise

    Immunoprecipitation: Tyrosine-phosphorylated form of LAT is not optimally recognized.
    Flow cytometry: Recommended dilution: 1-4 μg/mL, intracellular staining. Tyrosine-phosphorylated form of LAT is not optimally recognized.
    Western blotting: Recommended dilution: 1-2 μg/mL.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Hrdinka, Dráber, Stepánek, Ormsby, Otáhal, Angelisová, Brdicka, Paces, Horejsí, Drbal: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).

    Tedoldi, Paterson, Hansmann, Natkunam, Rüdiger, Angelisova, Du, Roberton, Roncador, Sanchez, Pozzobon, Masir, Barry, Pileri, Mason, Marafioti, Horejsí: "Transmembrane adaptor molecules: a new category of lymphoid-cell markers." in: Blood, Vol. 107, Issue 1, pp. 213-21, (2005) (PubMed).

  • Target

    LAT (Linker For Activation of T Cells (LAT))

    Andere Bezeichnung

    LAT

    Hintergrund

    Linker for activation of T cells,LAT (linker for activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.,IMD52

    Gen-ID

    27040

    UniProt

    O43561

    Pathways

    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
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