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GDF15 Antikörper (AA 49-308)

GDF15 Reaktivität: Human WB, IHC, IP, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3020659
  • Target Alle GDF15 Antikörper anzeigen
    GDF15 (Growth Differentiation Factor 15 (GDF15))
    Bindungsspezifität
    • 18
    • 15
    • 11
    • 8
    • 7
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 49-308
    Reaktivität
    • 88
    • 30
    • 23
    • 1
    • 1
    Human
    Wirt
    • 85
    • 12
    • 3
    • 1
    Kaninchen
    Klonalität
    • 85
    • 15
    • 1
    Polyklonal
    Konjugat
    • 52
    • 15
    • 9
    • 8
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GDF15 Antikörper ist unkonjugiert
    Applikation
    • 86
    • 54
    • 35
    • 16
    • 13
    • 13
    • 9
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Sequenz
    EDSRFRELRK RYEDLLTRLR ANQSWEDSNT DLVPAPAVRI LTPEVRLGSG GHLHLRISRA ALPEGLPEAS RLHRALFRLS PTASRSWDVT RPLRRQLSLA RPQAPALHLR LSPPPSQSDQ LLAESSSARP QLELHLRPQA ARGRRRARAR NGDHCPLGPG RCCRLHTVRA SLEDLGWADW VLSPREVQVT MCIGACPSQF RAANMHAQIK TSLHRLKPDT VPAPCCVPAS YNPMVLIQKT DTGVSLQTYD DLLAKDCHCI
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 49-308 of human GDF15 (NP_004855.2).
    Isotyp
    IgG
  • Applikationshinweise
    WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200,IP,1:50 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid freeze / thaw cycles
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Wang, Yang, Dai, Lu, Zhang, Keller: "Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion." in: Oncogene, Vol. 38, Issue 23, pp. 4540-4559, (2019) (PubMed).

    Han, Dai, Yousafzai, Wang, Wang, Zhou, Lu, Xu, Feng, Jin, Wang: "CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer." in: Oncotarget, Vol. 8, Issue 61, pp. 103557-103567, (2017) (PubMed).

    Tsui, Hsu, Chung, Lin, Feng, Lee, Chang, Juang: "Growth differentiation factor-15: a p53- and demethylation-upregulating gene represses cell proliferation, invasion, and tumorigenesis in bladder carcinoma cells." in: Scientific reports, Vol. 5, pp. 12870, (2016) (PubMed).

  • Target
    GDF15 (Growth Differentiation Factor 15 (GDF15))
    Andere Bezeichnung
    GDF15 (GDF15 Produkte)
    Synonyme
    GDF15 antikoerper, GDF-15 antikoerper, MIC-1 antikoerper, MIC1 antikoerper, NAG-1 antikoerper, PDF antikoerper, PLAB antikoerper, PTGFB antikoerper, SBF antikoerper, growth differentiation factor 15 antikoerper, GDF15 antikoerper, Gdf15 antikoerper
    Hintergrund
    The protein encoded by this gene belongs to the transforming growth factor-beta (TGF-beta) family. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress reponse program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress.,GDF15,GDF-15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Cytoskeleton,Extracellular Matrix,Bone,Growth factor,Immunology & Inflammation,Cytokines,Cardiovascular,Heart,Hypertrophy,GDF15
    Molekulargewicht
    34 kDa
    Gen-ID
    9518
    UniProt
    Q99988
    Pathways
    SARS-CoV-2 Protein Interaktom
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