Leptin Receptor Antikörper

Produktnummer ABIN3017146

Der Kaninchen Polyklonal Anti-Leptin Receptor-Antikörper wurde für WB und IF validiert. Er ist geeignet, Leptin Receptor in Proben von Human zu detektieren.

Kurzübersicht für Leptin Receptor Antikörper (ABIN3017146)

Target: Leptin Receptor (LEPR)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Leptin Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-Leptin Receptor Antikörper

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: A synthetic peptide of human LEPR

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:1000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Leptin Receptor

Target: Leptin Receptor (LEPR)

Andere Bezeichnung: LEPR

Hintergrund: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).,CD295,LEP-R,LEPRD,OB-R,OBR,LEPR,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Lipid Metabolism,AMPK Signaling Pathway,Endocrine and metabolic diseases,Obesity,Immunology & Inflammation,CD markers,Cardiovascular,Lipids,Fatty Acids,LEPR

Molekulargewicht: 96 kDa/102 kDa/103 kDa/109 kDa/132 kDa

Gen-ID: 3953

UniProt: P48357

Pathways: JAK-STAT Signalweg, AMPK Signaling, Feeding Behaviour