CNTF Receptor alpha Antikörper (AA 190-340)

Produktnummer ABIN3016492

Produktdetails anti-CNTF Receptor alpha Antikörper

Target: CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))

Bindungsspezifität: AA 190-340

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CNTF Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: NATAITFDEF TIVKPDPPEN VVARPVPSNP RRLEVTWQTP STWPDPESFP LKFFLRYRPL ILDQWQHVEL SDGTAHTITD AYAGKEYIIQ VAAKDNEIGT WSDWSVAAHA TPWTEEPRHL TTEAQAAETT TSTTSSLAPP PTTKICDPGE L

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 190-340 of human CNTFR (NP_001833.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:400 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-CNTF Receptor alpha Antikörper (ABIN3016492)

Yong, Groeger, von Bremen, Ruf: "Ciliary Neurotrophic Factor (CNTF) and Its Receptors Signal Regulate Cementoblasts Apoptosis through a Mechanism of ERK1/2 and Caspases Signaling." in: International journal of molecular sciences, Vol. 23, Issue 15, (2022) (PubMed).

Details zu CNTF Receptor alpha

Target: CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))

Andere Bezeichnung: CNTFR (CNTFR Produkte)

Hintergrund: This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.,CNTFR,Signal Transduction,Neuroscience,CNTFR

Molekulargewicht: 40 kDa

Gen-ID: 1271

UniProt: P26992

Pathways: JAK-STAT Signalweg, Feeding Behaviour