FMO3 Antikörper (AA 263-532)

Produktnummer ABIN3015686

Dieses Anti-FMO3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FMO3 in WB und IF. Geeignet für Human.

Kurzübersicht für FMO3 Antikörper (AA 263-532) (ABIN3015686)

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FMO3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-FMO3 Antikörper

Bindungsspezifität: AA 263-532

Sequenz: RFKHENYGLM PLNGVLRKEP VFNDELPASI LCGIVSVKPN VKEFTETSAI FEDGTIFEGI DCVIFATGYS FAYPFLDESI IKSRNNEIIL FKGVFPPLLE KSTIAVIGFV QSLGAAIPTV DLQSRWAAQV IKGTCTLPSM EDMMNDINEK MEKKRKWFGK SETIQTDYIV YMDELSSFIG AKPNIPWLFL TDPKLAMEVY FGPCSPYQFR LVGPGQWPGA RNAILTQWDR SLKPMQTRVV GRLQKPCFFF HWLKLFAIPI LLIAVFLVLT

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 263-532 of human FMO3 (NP_001002294.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:10 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FMO3

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Andere Bezeichnung: FMO3

Hintergrund: Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.,FMO3,FMOII,TMAU,dJ127D3.1,Signal Transduction,Endocrine & Metabolism,Drug metabolism,FMO3

Molekulargewicht: 60 kDa

Gen-ID: 2328

UniProt: P31513