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PLVAP Antikörper

Der Ratte Monoklonal Anti-PLVAP-Antikörper wurde für FACS, IHC und IHC (fro) validiert. Er ist geeignet, PLVAP in Proben von Maus zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN298904

Kurzübersicht für PLVAP Antikörper (ABIN298904)

Target

Alle PLVAP Antikörper anzeigen
PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Reaktivität

  • 30
  • 6
  • 1
Maus

Wirt

  • 22
  • 8
  • 4
Ratte

Klonalität

  • 23
  • 10
Monoklonal

Konjugat

  • 23
  • 5
  • 2
  • 2
  • 1
  • 1
Dieser PLVAP Antikörper ist unkonjugiert

Applikation

  • 32
  • 21
  • 16
  • 10
  • 6
  • 6
  • 6
  • 5
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon

MECA-32
  • Spezifität

    Recognizes murine plasmalemma vesicle-associated protein (PLVAP), a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumor angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.

    Aufreinigung

    Affinity purified

    Immunogen



    Type of Immunogen: Native protein

    Isotyp

    IgG2a
  • Applikationshinweise

    Approved: Flo, IHC, IHC-Fr (1:25 - 1:100)

    Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request.

    Kommentare

    Target Species of Antibody: Mouse

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    Lot specific

    Buffer

    PBS, 0.09 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    avoid freeze thaw cycles. Store undiluted.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.
  • Simon-Santamaria, Rinaldo, Kardas, Li, Malovic, Elvevold, McCourt, Smedsrød, Hirsch, Sørensen: "Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta." in: PLoS ONE, Vol. 9, Issue 11, pp. e111762, (2015) (PubMed).

  • Target

    PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

    Andere Bezeichnung

    PV1 / PLVAP

    Hintergrund

    Name/Gene ID: PLVAP

    Synonyms: PLVAP, gp68, FELS, Plasmalemma vesicle protein 1, PV-1, PV1

    Gen-ID

    83483

    UniProt

    Q9BX97
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