PLVAP Antikörper

Produktnummer ABIN298904

Produktdetails anti-PLVAP Antikörper

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser PLVAP Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: Recognizes murine plasmalemma vesicle-associated protein (PLVAP), a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumor angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.

Aufreinigung: Affinity purified

Immunogen:

Type of Immunogen: Native protein

Klon: MECA-32

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Approved: Flo, IHC, IHC-Fr (1:25 - 1:100)

Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request.

Kommentare:

Target Species of Antibody: Mouse

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: avoid freeze thaw cycles. Store undiluted.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.

Referenzen für anti-PLVAP Antikörper (ABIN298904)

Simon-Santamaria, Rinaldo, Kardas, Li, Malovic, Elvevold, McCourt, Smedsrød, Hirsch, Sørensen: "Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta." in: PLoS ONE, Vol. 9, Issue 11, pp. e111762, (2015) (PubMed).

Details zu PLVAP

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Andere Bezeichnung: PV1 / PLVAP (PLVAP Produkte)

Hintergrund: Name/Gene ID: PLVAP

Synonyms: PLVAP, gp68, FELS, Plasmalemma vesicle protein 1, PV-1, PV1

Gen-ID: 83483

UniProt: Q9BX97