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PLVAP Antikörper

PLVAP Reaktivität: Human WB, FACS, IHC (fro), IF Wirt: Maus Monoclonal 174-2 unconjugated
Produktnummer ABIN2192062
  • Target Alle PLVAP Antikörper anzeigen
    PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))
    Reaktivität
    • 27
    • 7
    • 1
    Human
    Wirt
    • 21
    • 6
    • 5
    Maus
    Klonalität
    • 22
    • 9
    Monoklonal
    Konjugat
    • 18
    • 5
    • 3
    • 2
    • 2
    • 2
    Dieser PLVAP Antikörper ist unkonjugiert
    Applikation
    • 29
    • 21
    • 16
    • 9
    • 6
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
    Sterilität
    0.2 μm filtered
    Klon
    174-2
    Top Product
    Discover our top product PLVAP Primärantikörper
  • Applikationshinweise
    For immunohistology, flow cytometry, immunofluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Niemelä, Elima, Henttinen, Irjala, Salmi, Jalkanen: "Molecular identification of PAL-E, a widely used endothelial-cell marker." in: Blood, Vol. 106, Issue 10, pp. 3405-9, (2005) (PubMed).

    Carson-Walter, Hampton, Shue, Geynisman, Pillai, Sathanoori, Madden, Hamilton, Walter: "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 21, pp. 7643-50, (2005) (PubMed).

  • Target
    PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))
    Andere Bezeichnung
    Plasmalemma Vesicle Associated Protein (PLVAP Produkte)
    Synonyme
    MECA32 antikoerper, Pv1 antikoerper, FELS antikoerper, PV-1 antikoerper, PV1 antikoerper, gp68 antikoerper, plasmalemma vesicle associated protein antikoerper, Plvap antikoerper, PLVAP antikoerper
    Hintergrund
    The monoclonal antibody 174/2 reacts with human plasmalemma vesicle associated protein (PLVAP), also known as PV1, PAL-E and FELS. PLVAP is a 60 kDa type II transmembrane glycoprotein which tends to form homodimers. PLVAP is widely expressed in the vasculature of normal tissues. The vascular staining pattern of PLVAP is quite unique among the endothelial cell antigens, since expression of other antigens (like ICAM-1, P-selectin, E-selectin or VCAM-1) is not limited to vascular endothelial cells. PLVAP expression in the vascular endothelial cells of the CNS is lost in association with formation of an intact blood-brain barrier. However, in the endothelium of human brain tumors expression of PLVAP is specifically up-regulated, making it a suitable antiangiogenic target for brain tumor therapy and cerebral edema. Furthermore, PLVAP is expressed in the vasculature of most other human tumors and as such useful as marker for tumor angiogenesis.
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