ANO1 Antikörper (AA 904-986)

Produktnummer ABIN2962568

Dieses Anti-ANO1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ANO1 in IHC. Geeignet für Human.

Kurzübersicht für ANO1 Antikörper (AA 904-986) (ABIN2962568)

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ANO1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: DOG1-1

Produktdetails anti-ANO1 Antikörper

Bindungsspezifität: AA 904-986

Spezifität: Reacts with human DOG1.

Aufreinigung: Purified (protein G)

Immunogen: Synthetic peptide corresponding to aa 904-986 of human DOG1 (accession no. Q5XXA6).

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC(1 - 10 μg/mL)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, pH 7.4

Handhabung: Dilute in PBS or medium which is identical to that used in the assay system.

Lagerung: -20 °C

Informationen zur Lagerung: This antibody is stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Details zu ANO1

Target: ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))

Andere Bezeichnung: DOG1

Hintergrund: DOG1 (Discovered on GIST1), also known as TMEM16A and ANO1, has emerged in recent years as a promising biomarker for gastrointestinal stromal tumors (GIST). It was originally discovered through microarray expression profiling analysis as a gene that is highly expressed in GIST, and subsequent immunohistochemical studies have shown its use in its diagnosis. DOG1 antibodies are more sensitive than KIT antibodies in detecting tumors of gastric origin, tumors with epithelioid morphology, and tumors harboring PDGFRA mutation. DOG1 immunoreactivity is rarely observed in other mesenchymal and nonmesenchymal tumor types. These results support the use of DOG1 as a biomarker for GIST.

Anoctamin 1, ANO1 Calcium activated chloride channel Discovered on gastrointestinal stromal tumors protein 1 Oral cancer overexpressed protein 2, ORAOV2 Transmembrane protein 16A, TMEM16A Tumor-amplified and overexpressed sequence 2, TAOS2 Gene name : ANO1

Gen-ID: 55107

UniProt: Q5XXA6