Desmocollin 2 Antikörper

Produktnummer ABIN2856641

Der Kaninchen Polyklonal Anti-Desmocollin 2-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, Desmocollin 2 in Proben von Human zu detektieren.

Kurzübersicht für Desmocollin 2 Antikörper (ABIN2856641)

Target: Desmocollin 2 (DSC2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Desmocollin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Desmocollin 2 Antikörper

Kreuzreaktivität: Human

Produktmerkmale: Rabbit polyclonal antibody to Desmocollin 2 (desmocollin 2)
Desmocollin 2 antibody [C1C2], Internal

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Desmocollin 2. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu Desmocollin 2

Target: Desmocollin 2 (DSC2)

Andere Bezeichnung: desmocollin 2

Hintergrund: The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.

Cellular Localization: Cell membrane , Cell junction , desmosome

Molekulargewicht: 100 kDa

Gen-ID: 1824

UniProt: Q02487