RAMP2 Antikörper (C-Term)

Produktnummer ABIN2856615

Zitiert in 2+ Publikationen. Der Kaninchen Polyklonal anti-RAMP2 Antikörper (ABIN2856615) detektiert spezifisch RAMP2 in WB, IHC (p) und IHC (fro). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für RAMP2 Antikörper (C-Term) (ABIN2856615)

Target: RAMP2 (Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-RAMP2 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to RAMP2 (receptor (G protein-coupled) activity modifying protein 2)
RAMP2 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human RAMP2. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-RAMP2 Antikörper (ABIN2856615)

Edvinsson, Grell, Warfvinge: "Expression of the CGRP Family of Neuropeptides and their Receptors in the Trigeminal Ganglion." in: Journal of molecular neuroscience : MN, Vol. 70, Issue 6, pp. 930-944, (2020) (PubMed).

Blom, Giove, Pong, Blute, Eldred: "Evidence for a functional adrenomedullin signaling pathway in the mouse retina." in: Molecular vision, Vol. 18, pp. 1339-53, (2012) (PubMed).

Details zu RAMP2

Target: RAMP2 (Receptor (G Protein-Coupled) Activity Modifying Protein 2 (RAMP2))

Andere Bezeichnung: receptor activity modifying protein 2

Hintergrund: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.

Cellular Localization: Membrane, Single-pass type I membrane protein

Molekulargewicht: 20 kDa

Gen-ID: 10266

UniProt: O60895

Pathways: cAMP Metabolic Process, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling