HRH2 Antikörper (N-Term)

Produktnummer ABIN2856570

Dieses Anti-HRH2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HRH2 in WB, IF, IHC (p), IHC, ICC und FACS. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für HRH2 Antikörper (N-Term) (ABIN2856570)

Target: HRH2 (Histamine Receptor H2 (HRH2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HRH2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Produktdetails anti-HRH2 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to Histamine H2 Receptor (histamine receptor H2)
Histamine H2 Receptor antibody [N1], N-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Histamine H2 Receptor. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: NT2D1 , PC-3 , U87-MG , SK-N-SH

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.75 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-HRH2 Antikörper (ABIN2856570)

Adderley, Zhang, Breslin: "Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction." in: Microcirculation (New York, N.Y. : 1994), Vol. 22, Issue 4, pp. 237-48, (2016) (PubMed).

Kurtz, Moor, Souza-Smith, Breslin: "Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics." in: Microcirculation (New York, N.Y. : 1994), Vol. 21, Issue 7, pp. 593-605, (2015) (PubMed).

Details zu HRH2

Target: HRH2 (Histamine Receptor H2 (HRH2))

Andere Bezeichnung: histamine receptor H2

Hintergrund: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Cellular Localization: Cell membrane, Multi-pass membrane protein

Molekulargewicht: 40 kDa

Gen-ID: 3274

UniProt: P25021