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BRE Antikörper

Dieses Anti-BRE-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BRE in WB, IF, ICC und IP. Geeignet für Human.
Produktnummer ABIN2856093

Kurzübersicht für BRE Antikörper (ABIN2856093)

Target

Alle BRE Antikörper anzeigen
BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Reaktivität

  • 28
  • 25
  • 22
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 41
  • 2
Kaninchen

Klonalität

  • 43
Polyklonal

Konjugat

  • 19
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser BRE Antikörper ist unkonjugiert

Applikation

  • 32
  • 13
  • 13
  • 13
  • 10
  • 9
  • 8
  • 3
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Güteklasse

KO Validated
  • Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Rabbit Polyclonal antibody to BRCC45 (brain and reproductive organ-expressed (TNFRSF1A modulator))
    BRCC45 antibody

    Aufreinigung

    Purified by antigen-affinity chromatography.

    Immunogen

    Recombinant protein encompassing a sequence within the center region of human BRCC45. The exact sequence is proprietary.

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    Kommentare

    Positive Control: 293T , A431 , C8D30 , rat testis , HeLa

    Validation: KO/KD

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

    Konservierungsmittel

    Thimerosal (Merthiolate)

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target

    BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

    Andere Bezeichnung

    BRISC and BRCA1 A complex member 2

    Hintergrund

    Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between MERIT40/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.

    Cellular Localization: Cytoplasm , Nucleus

    Molekulargewicht

    44 kDa

    Gen-ID

    9577

    UniProt

    Q9NXR7

    Pathways

    Positive Regulation of Response to DNA Damage Stimulus
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