MMP7 Antikörper (C-Term)

Produktnummer ABIN2855888

Der Kaninchen Polyklonal Anti-MMP7-Antikörper wurde für WB, ELISA und IHC (p) validiert. Er ist geeignet, MMP7 in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für MMP7 Antikörper (C-Term) (ABIN2855888)

Target: MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-MMP7 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Rind (Kuh), Human, Maus, Ratte

Produktmerkmale: Rabbit polyclonal antibody to MMP7 (matrix metallopeptidase 7 (matrilysin, uterine))
MMP7 antibody [C2C3], C-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MMP7. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.45 mg/mL

Buffer: 1XPBS pH 7, 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-MMP7 Antikörper (ABIN2855888)

Cai, Sun, Duan, Qiu, Dai, Yang, He: "FHL2 promotes tubular epithelial-to-mesenchymal transition through modulating β-catenin signalling." in: Journal of cellular and molecular medicine, Vol. 22, Issue 3, pp. 1684-1695, (2019) (PubMed).

Luo, Liao, Liao, Chen, Huang, Fan, Liao: "The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma." in: World journal of surgical oncology, Vol. 16, Issue 1, pp. 36, (2018) (PubMed).

Oelusarz, Nichols, Grunz-Borgmann, Chen, Akintola, Catania, Burghardt, Trzeciakowski, Parrish: "Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney." in: Physiological reports, Vol. 1, Issue 5, (2013) (PubMed).

Details zu MMP7

Target: MMP7 (Matrix Metallopeptidase 7 (Matrilysin, Uterine) (MMP7))

Andere Bezeichnung: matrix metallopeptidase 7

Hintergrund: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Cellular Localization: Secreted , extracellular space , extracellular matrix

Molekulargewicht: 30 kDa

Gen-ID: 4316

UniProt: P09237

Pathways: Production of Molecular Mediator of Immune Response