GLB1 Antikörper

Produktnummer ABIN2855812

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GLB1 in WB, IF, ICC und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für GLB1 Antikörper (ABIN2855812)

Target: GLB1 (Galactosidase, beta 1 (GLB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GLB1 Antikörper

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Rabbit polyclonal antibody to beta-Gal (galactosidase, beta 1)
beta-Gal antibody [N2C3]

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human beta-Gal. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validation: Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.35 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-GLB1 Antikörper (ABIN2855812)

Chang, Su, Chen, Chen, Chen, Hsiao: "Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis." in: Molecular cancer, Vol. 16, Issue 1, pp. 135, (2018) (PubMed).

Details zu GLB1

Target: GLB1 (Galactosidase, beta 1 (GLB1))

Andere Bezeichnung: galactosidase beta 1

Hintergrund: This gene encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyzes the terminal beta-galactose from ganglioside substrates and other glycoconjugates. Defects in this gene are the cause of GM1-gangliosidosis and Morquio B syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.

Cellular Localization: Isoform 1: Lysosome , Isoform 2: Cytoplasm , perinuclear region

Molekulargewicht: 76 kDa

Gen-ID: 2720

UniProt: P16278

Pathways: Glycosaminoglycan Metabolic Process