Lamin B1 Antikörper

Produktnummer ABIN2855607

Dieses Anti-Lamin B1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Lamin B1 in WB, IP und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für Lamin B1 Antikörper (ABIN2855607)

Target: Lamin B1 (LMNB1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Lamin B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: KO Validated

Produktdetails anti-Lamin B1 Antikörper

Kreuzreaktivität: Hamster, Human, Maus

Produktmerkmale: Rabbit Polyclonal antibody to Lamin B1 (lamin B1)
Lamin B1 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human Lamin B1. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:20000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Validatio: KO/KD, Orthogonal

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Referenzen für anti-Lamin B1 Antikörper (ABIN2855607)

Siew, Chen, Chen, Chen, Chen, Soong, Wu, Chang, Chan, Lin, Liu, Chern: "Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease." in: Nature communications, Vol. 10, Issue 1, pp. 3473, (2019) (PubMed).

Silva, Pentz, Figueira, Arora, Lee, Hodson, Wischnewski, Deans, Azzalin: "FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops." in: Nature communications, Vol. 10, Issue 1, pp. 2253, (2019) (PubMed).

Hsieh, Wang, Changou, Chin, Yang, Lai, Lee, Yang, Whang-Peng, Liu, Lin, Mousa, Davis: "Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells." in: Oncotarget, Vol. 8, Issue 15, pp. 24237-24249, (2018) (PubMed).

Arora, Lee, Wischnewski, Brun, Schwarz, Azzalin: "RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells." in: Nature communications, Vol. 5, pp. 5220, (2014) (PubMed).

Details zu Lamin B1

Target: Lamin B1 (LMNB1)

Andere Bezeichnung: lamin B1

Hintergrund: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

Cellular Localization: Nucleus inner membrane, Lipid-anchor, Nucleoplasmic side

Molekulargewicht: 66 kDa

Gen-ID: 4001

UniProt: P20700

Pathways: Apoptose, Caspase Kaskade in der Apoptose